Phase 2 Brain Cancer Trial, Recruiting NCT03728673 Sponsor: University of Nebraska Condition: Brain Cancer
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Phase 2 Brain Cancer Trial, Recruiting

NCT03728673
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have been confirmed by laboratory testing to have a Grade IV glioma (a type of brain tumour)
  • People who have been recently diagnosed and are due to receive chemotherapy and/or radiation treatment
  • People whose general physical functioning falls within a certain range, meaning they are able to carry out some or all daily activities (confirm with trial site for exact details)
  • People aged 19 years or older
  • People with a life expectancy of more than 6 months
  • People who are able to read and sign a consent form agreeing to take part in the study
  • Women who could potentially become pregnant must return a negative pregnancy test at the time of enrolment
  • Women who could potentially become pregnant must either be post-menopausal (no periods for 2 or more years), have had a surgical procedure that prevents pregnancy, or be willing to use two forms of barrier contraception during the trial

Who may not be able to join:

  • People who have significant loss of vision in part of their visual field that would prevent them from completing all study tests
  • People who are unable to have an MRI scan
  • People with severely reduced kidney function (as measured by a specific kidney function test falling below a certain level)
  • People who screen positive for depression or anxiety at the time of enrolment
  • People who are already taking an antidepressant medication (specifically SSRIs or SNRIs)
  • People who have had problems tolerating SSRIs or SNRIs in the past

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 21 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Nicole A Shonka, MD, University of Nebraska

Phone: 402-836-9488

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
University of Nebraska
Registry
ClinicalTrials.gov
Start date
6 March 2019
Est. completion
1 June 2027

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Change in Cognition; Characterize the degree of change in cognition and brain function; Change in Psycho-social Functions - PROMIS Neuro-QoL Item Bank v1.0 - Depression; Change in Psycho-social Functions - PROMIS Neuro-QoL Item Bank v1.0 - Anxiety; Change in Psycho-social Functions - PROMIS Neuro-QoL Item Bank v1.0 - Fatigue

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov