PTSD Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are between 18 and 80 years of age
• People who are at least 3 months past the event that caused their mild traumatic brain injury (mTBI)
• People who have a confirmed history of mild traumatic brain injury, either with or without PTSD, as determined through specific standardised assessment tools used by the trial team
• People who report at least a moderate level of difficulty with at least one of four thinking or memory-related complaints, as measured by a specific symptom questionnaire (the Neurobehavioral Symptom Inventory)

Who may not be able to join:

• People who are currently taking part in another research study
• People who are not fluent in English, both in speaking and reading
• People who had epilepsy before their brain injury
• People who have been receiving treatment for active seizures in the past 6 months
• People who are currently taking medications that can lower the seizure threshold, including certain antipsychotics, trazodone, or tramadol
• People who have had surgery on blood vessels in the brain or on heart valves
• People who have a history of bleeding in the brain, blood vessel conditions affecting the brain, or degenerative brain disorders
• People who have a current or past diagnosis of a psychotic spectrum disorder, such as bipolar disorder or schizophrenia
• People with significant heart disease, as determined by a doctor reviewing their medical records
• People who are pregnant at the time of joining or at any point during the study
• People with reasons they cannot safely have an MRI or a type of brain stimulation treatment (called TMS/iTBS), such as claustrophobia or metal in the eyes, face, or brain
• People who have implanted medical devices such as a cardiac pacemaker or defibrillator, cochlear implant, nerve stimulator, or metal clips in the brain
• People diagnosed with a moderate or severe traumatic brain injury (for example, loss of consciousness lasting more than 30 minutes, or extended memory loss after the injury)
• People whose prescribed mental health medications have been changed — including starting, stopping, or adjusting the dose — within the 30 days before the study screening
• People who are taking prescribed central nervous system (CNS) stimulant medications and are not willing to stop taking them during the study
• People who test positive for opioids without a valid prescription, or people on prescribed opioids taking more than the equivalent of 200 mg of morphine per day
• People whose results on a memory and validity test suggest the answers may not be a reliable reflection of their actual abilities, as assessed by a neuropsychologist on the research team
• People who are actively suicidal with a plan to cause harm or a recent attempt, as identified through a structured clinical interview
• People showing signs of increased pressure in the brain, detected through an eye examination or a baseline MRI scan
• People with moderate or severe cannabis use disorder, defined by 4 or more specific symptoms on a clinical assessment tool
• People with severe alcohol use disorder, defined by 6 or more specific symptoms on a clinical assessment tool
• People with a resting systolic blood pressure of 170 or higher at baseline

Important: Always verify eligibility with the trial site directly before applying.