Phase 1 Brain Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing to provide written agreement to take part in the study, including healthy volunteers.
• Healthy volunteers who do not have any reason they cannot safely have an MRI scan.
• People who are already enrolled in a related study called the Stereotactic RadPath trial (study #2011-0370).
• People who are 18 years of age or older and are willing to attend all required visits and assessments.
• People who have a brain lesion that is either suspected to be, or has already been confirmed by biopsy to be, a primary brain tumour, and who are being considered for surgical removal of that tumour.
• People who are able to understand the study information and provide their own consent to participate.
• People who are willing to have an MRI scan (including specialised imaging of blood flow, water movement, and brain chemistry) within 14 days before the planned procedure, and ideally within 3 days.
• People whose kidneys are functioning well enough (a kidney function score above 60); people with moderate kidney function (score between 30 and 60) may still be considered, with a different contrast agent used if a contrast scan is medically necessary (confirm with trial site).
• People who are willing to provide separate signed consent for a specific type of scan called C13-Pyruvate MR Spectroscopy.

Who may not be able to join:

• People whose brain anatomy makes it unsafe to perform a stereotactic biopsy (a type of guided needle procedure).
• People who have certain implanted devices or medical conditions that make MRI unsafe, including but not limited to: pacemakers, automatic defibrillators, insulin pumps, nerve stimulators, cochlear implants, carotid sinus pacemakers, ferromagnetic clips in the brain or body, metallic fragments in the eye, non-MRI-safe wires, suspected faulty prosthetic heart valves, or certain types of ear implants.
• People who are pregnant, or who experience claustrophobia that does not improve with oral medication.
• People who have previously received treatment for a primary brain tumour, such as surgery (other than biopsy), radiation therapy, or chemotherapy. A previous biopsy alone does not disqualify someone. A past history of a non-brain cancer that is now in remission for more than 6 months, with no brain involvement, also does not disqualify someone.
• People who have a history of irregular heart rhythms (cardiac arrhythmia).

Important: Always verify eligibility with the trial site directly before applying.