Phase 2 Melanoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older, of any race or sex, and have been diagnosed with skin melanoma confirmed by a medical test (such as a biopsy)
• You are generally able to carry out daily activities with little to no limitation (your doctor will assess this using a standard scale)
• Your blood, liver, kidney, and clotting functions are at healthy enough levels (your doctor will check this with tests)
• You have measurable areas of melanoma and have at least one lymph node that can be injected as part of the treatment
• Your original (primary) melanoma tumour has already been surgically removed
• Your melanoma is at stage III and a surgeon who specialises in melanoma has confirmed it can be operated on
• Your stage III melanoma can either be a new diagnosis or a return of melanoma that was previously treated at an earlier stage (stage I or II)
• You may have any type of BRAF gene status — this does not need to be known before joining
• You are willing and able to sign a consent form agreeing to take part

Who may not be able to join:

• You have melanoma that has spread to distant parts of the body (stage M1/metastatic melanoma)
• Your melanoma started in the mucous membranes (such as the mouth or nasal passages) or in the eye
• You have a history of another cancer (other than common skin cancer) within the past 3 years, or your melanoma is linked to a weakened immune system
• You have previously been treated with T-VEC, any other oncolytic virus therapy, pembrolizumab, or any similar immune checkpoint drug targeting PD-1, PD-L1, or PD-L2
• You have a history of certain autoimmune conditions affecting the lungs, kidneys, or blood vessels, or any autoimmune disease that required ongoing medical treatment in the past two years — though vitiligo or childhood asthma that has fully resolved may be acceptable (confirm with trial site)
• You currently have active cold sore or herpes-related skin outbreaks, have had serious complications from a herpes infection in the past, or regularly need antiviral medication (such as acyclovir) to manage herpes — occasional use of a topical antiviral cream may be acceptable (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.