Phase 1 Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have had mildly abnormal cervical cell results (called ASC-US or LSIL) that have been present for more than 6 months, confirmed by a specific type of cervical smear test
• People whose cervical samples have tested positive for a specific strain of HPV called HPV16 for more than 6 months, using an approved HPV test (having other HPV types at the same time is still permitted)
• People aged 19 years or older
• People whose blood test results show that the blood, liver, and kidney are functioning within acceptable ranges at the time of enrolment (the trial site will assess this through specific blood tests)
• People who are able to become pregnant must agree to use two forms of contraception (one hormonal and one barrier method) before joining the trial and for 3 months after it ends
• People who are able to understand the study and are willing to sign a written consent form
• People who are able to attend all required study visits and follow the study schedule

Who may not be able to join:

• People whose mildly abnormal cervical results test negative for HPV16
• People whose cervical tissue biopsy shows a higher level of abnormality known as CIN2 or above
• People who have a condition that weakens the immune system, or who have been taking immune-suppressing medications (such as steroids) for a long period of time
• People who have previously received any HPV vaccine, whether preventive or therapeutic
• People who have taken part in another clinical trial or received another experimental treatment within 28 days before the first dose
• People with an uncontrolled ongoing illness, including active infection, unstable heart conditions, a heart rhythm problem, or a mental health or personal situation that would make it difficult to follow the study requirements
• People with a history of autoimmune disease such as multiple sclerosis (note: a history of thyroid inflammation, psoriasis, Sjögren's syndrome, or inflammatory bowel disease may still be permitted — confirm with the trial site)
• People who have had an allergic reaction to any of the ingredients used to prepare the study treatment
• People who are currently pregnant or breastfeeding
• People with an active or ongoing infection of HIV, hepatitis C (HCV), or hepatitis B (HBV)
• People who have previously had a LEEP procedure or surgical removal of part of the cervix (cervical conisation)
• People with a history of cancer, unless they have been free of the disease for 5 or more years (an exception may apply for certain fully removed skin cancers — confirm with the trial site)
• People who are unable or unwilling to sign a consent form

Important: Always verify eligibility with the trial site directly before applying.