Sickle Cell Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 70 years old.
• You are able to understand and agree to participate by giving your consent.
• You are willing to allow samples of your body fluids or tissues (such as saliva, urine, or blood) to be stored for future research.
• You are willing to provide one or more of the following: saliva, urine, blood, blood by-products, body fat tissue, airway brushing samples, and/or lung wash fluid samples.
• You are willing to allow genetic testing to be done on any samples collected from you.

Who may not be able to join:

For all participants:

• You are currently pregnant.
• You have tested positive for hepatitis B, hepatitis C, or HIV.
• You have a health condition that currently needs active medical treatment or close monitoring to keep you safe.
• You have any condition that the lead doctor feels would make participation unsafe for you (confirm with trial site).

If you are giving blood samples:

• Your blood's hemoglobin (iron-carrying protein) level is too low — below 10 g/dL if you are a woman, below 12 g/dL if you are a man, or below 6 g/dL if you have sickle cell disease or another long-term anemia.

If you are having a fat tissue (adipose) biopsy:

• You are currently taking blood-thinning medication.
• Your platelet count (cells that help blood clot) is below 100,000 per microliter.
• You have a history of keloid scarring (thick, raised scars that grow beyond the original wound).
• You have had a bad reaction to lidocaine or similar local numbing medications in the past.
• The lead doctor feels the procedure would not be safe for you (confirm with trial site).

If you are having a bronchoscopy (a procedure to look inside the airways and collect lung samples):

• Your blood clotting test results are outside the acceptable range (confirm with trial site).
• Your platelet count is below 150,000 per microliter.
• You are currently taking blood-thinning medication.
• You have taken aspirin within the last 2 weeks, or anti-inflammatory drugs (like ibuprofen) within the last 2 days before the procedure.
• You have a diagnosed lung condition, such as asthma, chronic bronchitis, cystic fibrosis, or bronchiectasis.
• You have had a respiratory (breathing) tract infection in the last 4 weeks.
• You have had a bad reaction to anesthetics (numbing or sedating medications) used in this type of procedure.
• You have smoked cigarettes in the last 3 months.
• You have a history of long-term opioid (strong painkiller) use.
• You have a history of drug or alcohol misuse.
• Your lung function test results fall below a certain level, indicating significantly reduced breathing capacity (confirm with trial site).
• You are currently experiencing airway spasms (confirmed by a physical exam).
• You have a known allergy to lidocaine.
• The lead doctor feels the procedure would not be safe for you (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.