Phase 3 Head and Neck Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• A tissue or cell sample (biopsy) has confirmed a diagnosis of head and neck cancer.
• The person is aged between 18 and 80 years old and is expected to live for more than 3 months.
• The person is generally well enough to carry out light activity and care for themselves (assessed using a standard performance scale called ECOG, with a score below 2).
• Blood clotting function is acceptable or any clotting problems can be corrected.
• Recent blood test results (taken within 7 days before the procedure) show that blood cell counts, kidney function, liver function, and protein levels all fall within the ranges required by the trial.
• At least one tumour that can be measured using standard imaging criteria (called RECIST v1.1).
• The person has advanced head and neck cancer that is not suitable for local treatments such as surgery, or whose cancer has continued to grow after those treatments were tried.
• The person is using appropriate birth control during treatment.
• The person is willing and able to attend scheduled visits, follow the treatment plan, and complete required tests.
• Signed consent has been given before joining the trial.

Who may not be able to join:

• People who have taken part in another clinical trial of a drug or device within the last 4 weeks.
• People who have a serious other illness that may affect their outlook, such as significant heart disease, poorly controlled diabetes, or a psychiatric condition.
• People who have another current cancer or a past history of a different cancer.
• People who are pregnant or breastfeeding.
• People who are unlikely to follow the trial schedule or requirements as assessed by the trial team.
• People whose blood clotting results fall below the minimum levels required for the artery infusion procedure (platelet count below 60,000/mm³ or clotting activity below 50%).
• People who require dialysis due to kidney failure or severe kidney disease.
• People with known severe hardening or narrowing of the arteries.
• People with known high blood pressure that is not under control (above 160/100 mmHg).
• People who are allergic to the chemotherapy drug adriamycin, contrast dye used in imaging, or lipiodol (an oil used in the procedure).
• People taking other medicines that could interfere with how the study drugs are processed by the body.
• People who are unable to tolerate the discomfort of an artery infusion procedure.

Important: Always verify eligibility with the trial site directly before applying.