Early Phase 1 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing and able to give written consent to take part voluntarily.
• You are a man or woman between 18 and 75 years old.
• You have been diagnosed with acute myeloid leukemia (AML) or a bone marrow condition called Myelodysplastic Syndrome (MDS) (this is for the first group in the trial).
• You have been diagnosed with one of several other blood or bone marrow conditions, including CMML, aCML, CML, CNL, myelofibrosis, or MDS/MPN overlap syndrome (this is for the second group in the trial).
• Your general health and ability to carry out daily activities meets a certain minimum level, as measured by a standard scoring tool (confirm with trial site).
• Your heart is functioning well enough that everyday activities cause little or no symptoms such as tiredness, shortness of breath, or chest pain.
• Your liver, kidneys, heart, and lungs are working well enough to be considered for a transplant, based on specific blood and scan results (confirm with trial site for exact values).
• If you could become pregnant, or if your partner could become pregnant, you agree to use reliable contraception before, during, and for 30 days after the treatment — and to tell your doctor immediately if pregnancy occurs or is suspected.
• If you are a woman who could become pregnant, you have a negative pregnancy test (urine or blood) within 4 weeks of starting the treatment.

Who may not be able to join:

• You are currently pregnant or breastfeeding.
• You have severe lung disease (COPD) that requires you to use supplemental oxygen.
• You have a history of a collapsed lung (spontaneous pneumothorax), prior chest surgery involving opening the chest, or radiation treatment directed at your lungs.
• A recent chest scan (within the last 60 days) shows a collapsed lung or significant scarring of the lungs.
• You currently have another active cancer, other than the blood or bone marrow conditions listed above.
• You currently have an active ear or sinus infection, or you have chronic sinus problems unless an ear, nose, and throat specialist has confirmed it is safe for you to participate.
• You have had sinus surgery within the last 5 years.
• You have had ear surgery (other than a minor procedure such as ear tubes or a small eardrum incision).
• You are not willing to stop smoking tobacco or using e-cigarettes starting 72 hours before the transplant and until you have fully recovered (nicotine replacement products such as patches or gum are allowed).
• You experience claustrophobia (fear of enclosed spaces).
• You have had repeated seizures at any point in the last 5 years.
• You have asthma that is not well controlled.
• You currently have a viral or bacterial infection that is not under control.
• You have had a serious fungal infection in the past 6 months that has not been reviewed and approved by an infectious disease specialist (confirm with trial site).
• You have received chemotherapy injected into the fluid around the spine within the last 2 weeks, or radiation to the head within the last 4 weeks, before starting the treatment.

Important: Always verify eligibility with the trial site directly before applying.