Phase 1 Thyroid Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with anaplastic thyroid cancer, confirmed by a tissue or cell sample (a result described as "consistent with" this diagnosis, alongside a thyroid mass, is also acceptable).
• Your tumor has been tested and found to have a specific genetic change called a BRAF mutation (V600E or V600K).
• You are well enough to carry out basic daily activities and care for yourself (your doctor will assess this using a standard scale).
• Your blood test results show healthy enough levels of white blood cells, red blood cells, and platelets.
• Your liver and kidney function blood tests are within an acceptable range.
• If you are a woman who could become pregnant, you have had a negative pregnancy test within 14 days before starting the study medication.
• You are willing and able to use highly effective contraception throughout the trial and for several months after the last dose (specific methods are required — confirm details with the trial site).
• You are able to understand the study and are willing to sign a consent form agreeing to take part.

Who may not be able to join:

• Your anaplastic thyroid cancer is at an early, removable stage (stage IVA) and you are planning to have surgery to remove it.
• You have previously had radiotherapy to your neck or chest in a way that would overlap with any radiation planned in this trial.
• You have received chemotherapy, targeted brain radiation, or external beam radiation within the last 2 weeks before starting the trial.
• You have taken certain targeted cancer medicines (oral multikinase inhibitors) within the last week before starting the trial.
• You are still experiencing significant side effects from a previous cancer treatment (with the exception of hair loss).
• You have previously been treated with a strong BRAF inhibitor or MEK inhibitor (though prior use of sorafenib is allowed).
• You are currently taking part in another clinical trial involving an experimental treatment.
• You are currently taking certain medications that are not permitted alongside the trial drugs (confirm specific medications with the trial site).
• You have another active cancer that is currently being treated.
• You have brain metastases (cancer that has spread to the brain) that are not well controlled, unless you have been on a stable dose of steroids for more than one week, or have been off steroids for at least two weeks before joining (confirm details with the trial site).
• You have a history of certain eye conditions, including a blocked vein in the retina, fluid build-up under the retina, uncontrolled glaucoma, or high pressure in the eye.
• You have moderate to severe heart failure (as rated by your doctor).
• You have an abnormal heart rhythm reading on an ECG (a specific electrical measurement of your heart is too high).
• You have a serious uncontrolled illness, such as an active infection requiring IV antibiotics, unstable heart problems, or a mental health or personal situation that would make it difficult to follow the trial requirements.
• You are pregnant or currently breastfeeding, as the trial drug may be harmful to an unborn or newborn baby.
• You are known to be HIV-positive or are taking combination antiretroviral therapy, due to possible interactions with the trial drugs.

Important: Always verify eligibility with the trial site directly before applying.