Phase 2 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 to 75 years old
• People who have been diagnosed with a type of blood cancer called CLL (Chronic Lymphocytic Leukaemia) or SLL (Small Lymphocytic Lymphoma), confirmed using standard diagnostic guidelines
• People who have not previously received treatment for CLL/SLL — those who received only brief, limited prior treatment may still be considered, provided it did not include certain chemotherapy combinations (such as CHOP or COP), fludarabine, bendamustine, or ibrutinib; chlorambucil or cyclophosphamide was given for less than 3 weeks; interferon was given for less than 6 months; and no meaningful response to that prior treatment was seen (confirm with trial site)
• People whose CLL/SLL now needs treatment, shown by at least one of the following signs: a drop in red blood cell levels, a drop in platelet levels, an enlarged spleen, significantly enlarged lymph nodes, a rapid rise in white blood cell counts, involvement of organs outside the lymph nodes (such as skin or kidneys), or symptoms such as unintentional weight loss of 10% or more in the past 6 months or severe fatigue affecting daily life
• People who are reasonably active and able to care for themselves, as measured by a standard health performance scale (score of 0 to 2 out of 4)
• People who are expected to survive for at least 3 months

Who may not be able to join:

• People who have had another type of cancer (other than CLL) within the past year, including lymphoma affecting the brain or spinal cord
• People whose CLL/SLL has transformed into a more aggressive form of lymphoma or progressed to a related condition called prolymphocytic leukaemia
• People who have active autoimmune conditions causing the immune system to attack their own red blood cells or platelets, and who require treatment for those conditions
• People with liver or kidney function that falls below the levels required for the trial, as shown by blood test results (confirm with trial site for specific values)
• People with a severe or uncontrolled infection
• People with a condition affecting the nervous system that is causing noticeable symptoms
• People with other serious health conditions that the trial doctor considers may affect the study, such as uncontrolled diabetes, stomach ulcers, or significant heart or lung disease
• People with ongoing, uncontrolled bleeding
• People who have had a serious, life-threatening bleeding episode in the past, particularly from a cause that cannot be corrected
• People who need to take blood-thinning (anticoagulant) medication continuously
• People who have had major surgery within the 30 days before joining (lymph node biopsy is not included in this restriction)
• Women who are pregnant or breastfeeding, or women of childbearing age who are unwilling to use contraception during the trial
• People with a known allergy to any medication used in the trial

Important: Always verify eligibility with the trial site directly before applying.