Phase 2 Leukaemia Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a type of blood cancer called CLL (Chronic Lymphocytic Leukemia) or SLL (Small Lymphocytic Lymphoma).
• Your disease is considered "active," meaning you have at least one of the following: lost 10% or more of your body weight in the last 6 months; have extreme tiredness; have had unexplained fevers above 100.5°F for 2 or more weeks; have had unexplained night sweats for more than a month; or have worsening blood counts, an enlarged spleen, swollen lymph nodes, or rapidly increasing white blood cell counts.
• You have a blood cancer specialist (hematologist/oncologist) who will take over your care and continue your treatment after the initial phase of the study.
• You have had a specific blood test (G6PD) done to check which medications can safely be used to manage a potential side effect called tumor lysis syndrome.
• You have had genetic (HLA) testing done to check whether you may have a sensitivity to a common medication called allopurinol.
• You are 18 years of age or older.
• You are generally able to carry out normal daily activities, or are limited only in physically strenuous activity (confirm with trial site).
• If you are sexually active and capable of having children, you agree to use an accepted form of birth control for the entire time you are on the study treatment.
• You are willing and able to attend all required study visits and procedures, and are able to swallow capsules without difficulty.
• You are able to understand what the study involves and are willing to sign a consent form.

Who may not be able to join:

• You are currently pregnant or breastfeeding.
• You have an active infection that is not under control.
• You have another serious illness or organ problem that the study doctor believes could put your health at risk.
• You have another cancer that is currently growing or requires active treatment — though some exceptions may apply, such as certain skin cancers, cervical cancer caught early, cancers you have been free of for more than 2 years, or some cancers being managed with hormone therapy (confirm with trial site).
• Your CLL has transformed into a more aggressive type of lymphoma (called Richter's Transformation).
• You have previously been treated with a type of drug called a BCL-2 inhibitor (for example, venetoclax).
• You are currently taking certain medications that strongly affect how the study drug is processed by your body (confirm with trial site which medications apply).
• You have a condition that seriously affects your digestive system and how your body absorbs medications.
• You have an uncontrolled autoimmune condition that is causing your body to destroy its own red blood cells or platelets.
• You are currently receiving other cancer treatments such as chemotherapy, immunotherapy, or radiation therapy.
• Your blood counts (specifically, infection-fighting white blood cells or platelets) are below certain minimum levels — though an exception may be made if the study doctor believes this is caused by the CLL itself and is expected to improve with treatment (confirm with trial site).
• Your liver function tests show bilirubin levels more than 3 times the normal upper limit.
• You have a serious mental health condition or significant difficulty with thinking or memory that would make it hard to safely follow the study requirements.

Important: Always verify eligibility with the trial site directly before applying.