Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Part 1 – Chemotherapy phase:

• People who have been diagnosed with a specific type of invasive cervical cancer (adenocarcinoma, adenosquamous, or squamous cell type) where the tumour measures more than 2 cm but no larger than 4 cm, confirmed by MRI scan.
• People who are premenopausal and wish to preserve their fertility.
• People who have not received any previous treatment for their cervical cancer at the time of joining the trial.
• People who are generally well enough to carry out daily activities, based on a standard health performance scale (ECOG score of 2 or below).
• People whose blood tests show that their organs (such as kidneys, liver, and bone marrow) are working normally within 7 days before treatment is due to start.
• People who have no active, uncontrolled infection at the time of joining (those already taking antibiotics may still be eligible).
• People whose cancer can be measured using standard imaging guidelines (RECIST 1.1).
• People who are willing and able to understand and sign a consent form.
• People who agree to use effective contraception before, during, and for at least one year after any fertility-sparing surgery, and who have a negative pregnancy blood test within 72 hours before registering for the trial.

Part 2 – Fertility-sparing surgery phase:

• People who have completed all 3 cycles of chemotherapy as part of this trial and whose tumour has either disappeared completely or shrunk to less than 2 cm on both physical examination and MRI scan.

Who may not be able to join:

Part 1 – Chemotherapy phase:

• People who have already had chemotherapy, radiotherapy, or surgery to treat their cervical cancer.
• People who are currently taking part in another clinical trial involving an experimental treatment.
• People who have another type of cancer that currently requires active treatment.
• People who have cancer that has spread to the brain.
• People who have had a significant allergic reaction to drugs similar in makeup to paclitaxel, carboplatin, or cisplatin — the chemotherapy drugs used in this trial.
• People with serious ongoing or uncontrolled health conditions, such as active infection, heart failure, unstable chest pain, irregular heartbeat, or significant mental health or personal circumstances that could affect their ability to participate safely.
• People who are currently pregnant or breastfeeding.
• People with any other condition that the trial doctor considers would make participation unsafe or difficult, such as a bowel blockage, difficulty swallowing, ongoing inflammation or infection, or significant social or psychological challenges (confirm with trial site).

Part 2 – Fertility-sparing surgery phase:

• People who were unable to complete all 3 cycles of chemotherapy.
• People whose cancer did not respond well enough to chemotherapy, as determined by the trial doctor.
• People whose tumour remains larger than 2 cm after chemotherapy, or whose cancer grew or spread during chemotherapy.

Important: Always verify eligibility with the trial site directly before applying.