Phase 1 Thyroid Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a cancer that cannot be cured with surgery, specifically: advanced melanoma (stage IIIC or IV, including cases where cancer has spread to the brain), or another type of solid tumor (not in the brain) that has stopped responding to all standard treatments available to you
• Your tumor has been tested and shown to have a specific protein on it called IL13Rα2, at a level meeting the study's required amount (confirm with trial site)
• You are between 18 and 74 years old
• You are generally well enough to carry out light activity and care for yourself — rated 0 or 1 on a standard medical fitness scale (confirm with trial site)
• You have at least one area of cancer that can be measured, either by standard imaging or by photographs with a ruler for skin lesions
• Your blood counts and immune cell levels are within acceptable ranges, checked within the past 30–60 days before joining and again shortly before treatment starts (confirm with trial site)
• Your liver enzyme levels are within an acceptable range at the time of enrollment (confirm with trial site)
• Your bilirubin (a substance processed by your liver) is within an acceptable level, unless you have a known condition called Gilbert's syndrome (confirm with trial site)
• Your kidney function is within an acceptable range (confirm with trial site)
• If you have melanoma, your cancer must have gotten worse after at least one round of standard treatment, including immunotherapy, and targeted therapy if your tumor has a specific gene change called BRAF V600 — and there are no other curative treatment options available to you
• You are willing and able to undergo a procedure to collect immune cells from your blood (called leukapheresis), unless you are receiving a second infusion as part of the study
• You are willing and able to sign a consent form agreeing to take part in the study

Who may not be able to join:

• Not enough usable immune cells could be collected from your blood during the collection procedure (does not apply if you are receiving a second infusion)
• You have had an allergic reaction to any of the medications used in this study, including the chemotherapy drugs cyclophosphamide or fludarabine
• You have received any cancer treatment, including immunotherapy, within 14 days before the start of the study's chemotherapy
• You currently have active, untreated cancer that has spread to the brain — though previously treated brain metastases that are now stable may be acceptable (confirm with trial site)
• You are currently taking or likely to need steroid tablets or other immune-suppressing medications, or you have taken steroid tablets within the past 2 weeks — though steroid inhalers, creams, or steroids taken to replace hormones your body cannot make are generally acceptable (confirm with trial site)
• You are HIV positive or have another condition that weakens your immune system in a way that would increase the risk of serious infections
• You have hepatitis B or C infection with signs of ongoing liver damage
• You have dementia or a serious mental health condition that would prevent you from understanding and agreeing to take part in the study
• Your lung function tests show your lungs are not working well enough to meet the study's requirements (confirm with trial site)
• You have a history of significant heart problems, symptoms of reduced blood flow to the heart, or irregular heartbeat, and your heart's pumping strength is below the required level on a heart stress test
• You have certain abnormal heart rhythm readings on an ECG, or a very fast or very slow resting heart rate, and a heart specialist has not cleared you to participate — some heart rhythm problems will automatically exclude you from the study (confirm with trial site)
• You are pregnant or breastfeeding; women who could become pregnant must use effective contraception during treatment and for 6 months afterward, and must have a negative pregnancy test before starting
• You have another active cancer at the same time that could interfere with measuring how well this treatment is working

Important: Always verify eligibility with the trial site directly before applying.