Phase 2 OCD Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are an adult (any gender), and the study aims to recruit equal numbers of men and women, including people from different racial and ethnic backgrounds
- You are able and willing to take part in all study activities, including health assessments and MRI brain scans
- You have signed a consent form approved by the study's ethics committee
- (For people with OCD) You have a confirmed diagnosis of OCD based on a clinical assessment
- (For people with OCD) Your OCD symptoms are at least moderately severe, based on a standard symptom rating scale
- (For people with OCD) You are not currently taking any psychiatric medications, except occasionally taking something to help with sleep
- (For people with OCD) You are looking for treatment and your doctor considers a specific antidepressant medication (fluoxetine) appropriate for you
- (For people with OCD who can become pregnant) You are not pregnant, not planning to become pregnant, and are willing to use reliable contraception throughout the study
- (For healthy volunteers) You do not have any current mental health diagnosis and have no known or suspected family history of OCD, Tourette syndrome, hoarding disorder, body dysmorphic disorder, or compulsive grooming disorders in a close relative
Who may not be able to join:
- You have an unstable medical, psychiatric, or neurological condition that may need urgent treatment, including serious concerns about suicide
- You have had a substance use disorder (such as alcohol or drug dependency) in the past 6 months
- You have taken psychiatric medications in the past 8 weeks (except occasionally using a sleep aid or painkiller)
- You have taken a sleep aid or prescription painkiller within the past 3 days before a scan appointment
- You have a history of a psychotic disorder or bipolar mania
- A urine drug test shows evidence of substance use
- You have a significant neurological disease or a history of serious head injury, including a concussion where you lost consciousness for an extended period
- You are pregnant
- You have any metal implants in your body or any other reason you cannot safely have an MRI scan
- You have severe claustrophobia, significant back pain, or any condition that would make lying still in an MRI scanner for an extended period difficult
- (For people with OCD) You have previously had an allergic reaction or bad reaction to fluoxetine or a similar antidepressant, or have another medical reason you should not take fluoxetine
- (For people with OCD) You have already tried fluoxetine at a sufficient dose and length of time in the past and it did not work for you
- (For people with OCD) You are currently taking blood-thinning medication (Coumadin/warfarin) or a type of antidepressant called MAOIs
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Christopher Pittenger, MD, PhD, Professor of Psychiatry; Director, Yale OCD Research Clinic
Phone: 1-855-623-9253
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Obsessive-compulsive severity change
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.