Phase 3 Tuberculosis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People aged 15 years or older
- People who have been diagnosed with tuberculous meningitis (a serious brain infection caused by tuberculosis), confirmed or suspected based on specific medical test results or scoring systems (confirm with trial site)
- People who have provided signed informed consent to participate
Who may not be able to join:
- People who have already received more than 5 days of tuberculosis treatment
- People with severe kidney disease, where the kidneys are working at a very low level
- People with a very low white blood cell count (a type of cell that fights infection)
- People with a low red blood cell count or low haemoglobin (a sign of significant anaemia)
- People with significantly elevated bilirubin levels in the blood, which can indicate liver or blood problems
- People with a very low platelet count (platelets help blood to clot)
- People with significantly elevated liver enzyme levels (a sign the liver may be under stress)
- People with signs of serious liver disease or liver failure
- Women who are more than 17 weeks pregnant, or who are breastfeeding
- People who are fully conscious and alert but who have significant nerve damage affecting their limbs, rated at a certain severity level (confirm with trial site)
- People whose tuberculosis bacteria have been shown to be resistant to the antibiotic rifampicin
- People whose spinal fluid test results suggest a different type of infection (such as bacterial or fungal meningitis)
- People with signs of active bleeding anywhere in the body, such as coughing up blood, bleeding in the gut, blood in the urine, or bleeding in the brain
- People from whom a spinal fluid sample cannot be collected, unless tuberculosis has already been confirmed through another type of test and there is other evidence of meningitis
- People who have had major surgery within the two weeks before joining the trial
- People who are currently taking aspirin on an ongoing basis (for example, for heart health)
- People currently taking certain other medications that cannot be safely stopped and that are known to interact with the trial drugs
- People with a known history of bleeding in the brain, stomach ulcers, gut bleeding within the past 3 months, a known allergy to the trial drugs, a condition called porphyria, or a condition involving high uric acid levels or gout
- People where the trial doctor has concerns that participation would not be safe or practical for that individual
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Fabrice Bonnet, M.D., Ph.D., University Hospital, Bordeaux
Phone: +33 (0)5 56 79 58 26
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Rate of all-cause death
Can't join this trial?
Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.