Sickle Cell Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
This trial has four separate groups. People may be considered for one of the following:
- Group 1 (Healthy volunteers): Children and teenagers aged 8–18 who do not have sickle cell disease (SCD).
- Group 2 (SCD patients without certain treatments): Children and teenagers aged 8–18 who have sickle cell disease, have not had gene therapy or a bone marrow transplant, are not receiving regular ongoing blood transfusions, and have not had any blood transfusion in the past 3 months.
- Group 3 (SCD patients who have had gene therapy): Children and teenagers aged 8–18 who have sickle cell disease and have already received gene therapy at least one month before joining the trial.
- Group 4 (SCD patients on regular transfusions): Children and teenagers aged 8–18 who have sickle cell disease and are currently receiving regular ongoing blood transfusions.
Who may not be able to join:
- People who have an electrical device implanted in their body, such as a pacemaker or an infusion pump.
- People who have metal implants in their body, such as surgical clips, an artificial heart valve with steel parts, metal fragments or shrapnel, or certain other metal devices.
- People who are wearing or have ferromagnetic (strongly magnetic) metal objects on or in their body, such as certain jewellery or metal clips.
- Women of childbearing age who are pregnant, think they may be pregnant, are breastfeeding, or are trying to become pregnant.
- People who have a medical condition that makes them prone to seizures or who are likely to experience severe claustrophobia (fear of enclosed spaces).
- People who have a higher-than-normal risk of cardiac arrest (when the heart suddenly stops).
- People who would need sedation (medication to make them sleepy or calm) in order to undergo an MRI scan.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Ellen Grant, MD, Boston Children's Hospital
Phone: 857-218-5111
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Accuracy of FDNIRS-DCS in measuring blood oxygenation of the brain
Can't join this trial?
Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.