Brain Cancer Trial, Recruiting NCT04181684 Sponsor: University of Maryland, Baltimore Condition: Brain Cancer
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Brain Cancer Trial, Recruiting

NCT04181684
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have been diagnosed with a WHO Grade II, III, or IV brain tumour (glioma) that has come back or continued to grow, as shown on a brain scan
  • People who received radiation therapy as part of their original glioma treatment
  • People who have not previously had a second course of radiation therapy for this tumour, regardless of how many times the tumour has recurred
  • People whose brain MRI (with contrast dye) shows an enhancing tumour no larger than 6 cm, taken within 60 days before joining the trial
  • People who have had a full physical and neurological examination within 30 days before joining the trial
  • People with a Karnofsky performance score of 60% or higher — a measure used by doctors to assess how well a person is able to carry out daily activities — within 30 days before joining (confirm with trial site)
  • People aged 22 years or older
  • People whose previous radiation treatment was completed at least 8 weeks before joining the trial
  • People who have read and signed an approved consent form agreeing to take part
  • People who could become pregnant or could make a partner pregnant must agree to use effective contraception during the trial and for 6 months after it ends
  • Women who could become pregnant must have a negative pregnancy test within 28 days before joining the trial

Who may not be able to join:

  • People who are not considered suitable candidates for stereotactic biopsy (a type of surgical tissue sample) or laser ablation (a procedure to destroy tumour tissue with laser heat)
  • People with serious heart conditions, including uncontrolled heart rhythm problems, or people who have experienced a heart attack, severe chest pain, heart bypass surgery, heart failure, stroke, mini-stroke (TIA), or blood clot in the lungs within the 6 months before joining
  • People whose tumour is located in the lower part of the brain (infratentorial region) or has spread along the lining of the brain or spinal cord
  • People who are unable to undergo an MRI scan
  • People who are pregnant or currently breastfeeding

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 14 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Phone: 410-328-6080

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
8 January 2020
Est. completion
1 December 2026

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Adverse Events

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 14 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov