Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

"Who might be able to join this trial:

• People who are 18 years of age or older (or 19 and older if living in Nebraska).
• People whose overall health and cancer situation falls within a certain range, as measured by standard medical scoring tools used for brain cancer patients, and who have a functional ability score of 60 or above out of 100 (confirm with trial site).
• People who have a known or suspected solid cancer that has spread to the brain, with up to four brain tumours, each no larger than 4 cm, where surgery is planned to remove at least one tumour and a specific type of chemotherapy wafer (called Gliadel) is planned to be placed at one surgical site.
• People whose blood test results show it is safe for them to have surgery, as judged by their neurosurgeon (blood transfusions are allowed beforehand if needed to reach the required levels).
• Women who could become pregnant must have had a negative pregnancy test within 7 days of starting the study. Women who are not considered to be of childbearing potential include those aged 55 or older with no periods for two years, or anyone who has had their uterus and/or both ovaries surgically removed.
• People with a normal blood clotting result (a specific clotting measurement called INR must be 1.3 or below).
• People whose doctor estimates they are likely to live for at least 3 months or more.
• People who are willing and able to give their consent and follow the requirements of the trial.

Who may not be able to join:

• People who have previously had surgery or radiation treatment to the area of the brain being considered for surgery in this trial.
• People who have previously had whole-brain radiation therapy.
• People whose cancer is specifically lymphoma, germ cell cancer, small cell lung cancer, or anaplastic thyroid cancer.
• People whose cancer has spread to the lining of the brain and spinal cord (a condition called leptomeningeal disease).
• People who have a brain-related degenerative condition, such as dementia.
• People whose brain tumour is larger than 4 cm.
• People with a functional ability score below 60 out of 100 on the standard medical scoring tool used in this trial (confirm with trial site).
• People who are unable or unwilling to follow the requirements of the trial.
• People with another significant medical, physical, or mental health condition, or abnormal test results, that the trial doctor believes could interfere with the trial or make it unsafe to participate.
• People who are already taking part in another clinical trial for a treatment.
• People with serious heart or lung conditions, including: moderate-to-severe heart failure within the past 6 months (unless it is well managed with medication and causing no symptoms); uncontrolled or significant heart disease; serious irregular heart rhythms; or significant breathing difficulties rated at a certain level of severity (confirm with trial site).
• People with a metabolic or psychological condition that, in the trial doctor's opinion, may affect their ability to follow the trial or may put them at greater risk of complications.
• People who have a condition that causes abnormal bleeding, or who need to take blood-thinning or anti-clotting medications (including certain common pain relief medicines such as anti-inflammatories) at the time of planned surgery, where stopping those medications is not possible.
• People who are unable to have MRI scans.

Important: Always verify eligibility with the trial site directly before applying."