Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 to 70 years old
• People who have been diagnosed with a brain tumour called GBM (glioblastoma) or a lower-grade brain tumour (such as oligodendroglioma, astrocytoma, or related types), confirmed by tissue testing
• People whose tumour has come back, either confirmed by a new biopsy or surgery (done at least 2 weeks before joining), or confirmed by a brain scan (MRI) showing at least one measurable area of tumour growth
• People who have previously received standard combined radiation and chemotherapy treatment, plus at least one cycle of chemotherapy, after their first diagnosis
• People whose last radiation treatment was at least 3 months before joining the trial
• People whose last chemotherapy was completed at least one full chemotherapy cycle interval before joining, with side effects mostly resolved (except hair loss or skin colour changes)
• People with a general health and functioning score of 60 or above on the Karnofsky scale, which measures ability to carry out daily activities (confirm with trial site)
• People taking steroid medications whose dose has been stable or reduced for at least 5 days before their baseline brain scan
• People taking certain anti-seizure medications that affect drug metabolism must have switched to a different type of anti-seizure medication at least 1 week before joining
• People whose doctors estimate they have a life expectancy of at least 12 weeks
• People with adequate blood counts, liver function, kidney function, and heart function, confirmed by blood tests and a heart tracing (ECG) taken within 7 days before starting treatment (confirm with trial site for specific values)
• People of childbearing potential who agree to use effective contraception throughout the study
• People who have voluntarily agreed to take part and have signed a consent form

Who may not be able to join:

• People who are unable to have an MRI scan, for example due to having a pacemaker or metal dental implants
• People who are currently taking part in another clinical trial involving an experimental treatment
• People with a history of serious allergic reactions to medications similar to those used in this trial
• People who have previously received an organ transplant
• People who have HIV or syphilis (Treponema pallidum) infection
• People with serious heart disease, or whose heart tracing (ECG) shows certain specific abnormal changes
• People who have difficulty absorbing tablets or capsules by mouth, for example due to ongoing vomiting, diarrhoea, or a bowel blockage
• People who have had significant bleeding problems in the 3 months before joining, such as stomach or bowel bleeding, a bleeding stomach ulcer, a perforated bowel, a high level of hidden blood in the stool, bleeding in or around the brain, or blood vessel inflammation
• People who have experienced a blood clot or stroke-related event in the 6 months before joining, such as a stroke, mini-stroke (TIA), brain bleed, deep vein thrombosis, or pulmonary embolism
• People with a bleeding disorder who are being treated with blood-thinning or clot-dissolving medications
• People whom the trial doctors consider unsuitable for other medical reasons

Important: Always verify eligibility with the trial site directly before applying.