Phase 1 Leukaemia Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with acute myeloid leukemia (AML) that has come back or stopped responding to treatment, or you have a high-risk form of a bone marrow condition called MDS, confirmed by a tissue test.
• You are 18 years of age or older.
• Your heart, liver, kidneys, and other organs are working well enough to participate (confirm with trial site).
• Doctors expect you to live for at least 12 weeks.
• You are generally well enough to carry out daily activities with little or no limitation (rated 0 or 1 on a standard fitness scale used by doctors).
• You are able to understand what the study involves and are willing to sign a consent form (a legal representative may sign on your behalf if needed).
• Your white blood cell count is below a certain level — medication may be used beforehand to help meet this requirement (confirm with trial site).

Who may not be able to join:

• You have a specific type of leukemia called acute promyelocytic leukemia (APL).
• You have received certain cancer treatments recently — the required waiting period since your last treatment must have passed before joining (confirm exact timeframes with trial site).
• You have serious uncontrolled health problems, such as an active uncontrolled infection, severe heart failure, unstable chest pain, significant heart rhythm problems, or a mental health condition that would make it hard to follow the study rules.
• You have an active infection requiring antibiotic or antifungal treatment, or you have active hepatitis B, hepatitis C, or HIV.
• You have had a stem cell transplant using someone else's cells at any time, or your own cells within the past 12 months.
• Your leukemia has spread to your brain or spinal fluid and is not under control.
• You have previously been treated with a specific type of drug that targets a protein pathway called MDM2-p53.
• The study doctor feels, for any reason, that joining the trial would not be safe or suitable for you.
• You have had another type of cancer in the past 2 years — though some exceptions may apply, such as certain skin cancers or early-stage cancers that were fully treated (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.