Phase 2 Head and Neck Cancer Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People diagnosed with a specific type of throat cancer (squamous cell cancer of the oropharynx) that tests positive for a protein called p16
- People whose cancer is at a certain stage — classified as Stage III or Stage IVa under a standard cancer staging system (confirm with trial site for exact stage details)
- People who have not yet received any treatment for this cancer
- People with no sign that the cancer has spread to distant parts of the body
- People whose overall health is considered good enough for surgery, and whose tumour a surgeon has assessed as removable through the mouth with clear margins
- People aged over 18 years
- People with a general health and activity level above a certain threshold, as measured by standard medical scoring tools (confirm with trial site)
- People whose blood counts and kidney function meet specific minimum levels (confirm with trial site for exact values)
- People who have signed the study consent form
- People with no other cancers in the past 5 years, except for certain common skin cancers (basal cell carcinoma or squamous cell carcinoma of the skin)
- People who agree to use effective contraception during the study; women who could become pregnant must have a negative pregnancy test and must not be breastfeeding
Who may not be able to join:
- People with a more advanced stage of cancer (T4) that cannot be removed without removing an organ
- People whose tumour tests negative for the p16 protein
- People with a more advanced level of lymph node involvement, classified as N3 or Stage IVB
- People with 5 or more cancerous lymph nodes in the neck at the time of diagnosis
- People whose cancer has spread to distant parts of the body (Stage IVC)
- People whose scans show the cancer has clearly broken out of the lymph node walls
- People whose anatomy does not allow the surgical approach through the mouth
- People who have previously had a head or neck cancer at any time (other than certain skin cancers)
- People with a second cancer currently present, or a history of cancer within the past 5 years (with some exceptions for certain skin cancers or an early-stage cervical cancer that was fully treated)
- People with pre-existing nerve damage, even at a mild level
- People who have previously been treated with certain chemotherapy drugs called Taxanes or Cisplatin
- People with an active infection at the time of enrolment
- People with other serious health conditions that could interfere with treatment or follow-up, or who are not able to give informed consent
- People currently taking part in another clinical trial involving an investigational treatment
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Nader Sadeghi, MD, McGill University Health Centre/Research Institute of the McGill University Health Centre
Phone: 514-934-1934
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Primary outcome: progression free survival.
Can't join this trial?
Data last synced from ClinicalTrials.gov: 8 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.