Phase 1 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who were over 18 years old at the time of their lung cancer diagnosis.
• People who have been diagnosed with non-small cell lung cancer, confirmed through a tissue sample test.
• People whose physical functioning has been assessed by their doctor as limited — able to care for themselves but unable to do any work (this is called ECOG Performance Status 2; confirm with trial site).
• People whose cancer is at an advanced stage (Stage IIIc or Stage IV).
• People with Stage IIIc disease where standard chemotherapy combined with radiation is either not suitable for them or has been declined by the patient.
• People with Stage IV disease where standard platinum-based chemotherapy is considered not appropriate or unsafe by their treating doctor, or has been declined by the patient.
• People whose recent blood test results meet certain minimum levels for white blood cells, platelets, kidney function (if a specific drug called pemetrexed is being offered), and liver enzymes (confirm with trial site for specific values).
• People who have small brain metastases (cancer that has spread to the brain) that are not causing symptoms.
• Women who could become pregnant must have a negative pregnancy test and must agree to use effective contraception during the trial and for 120 days after the last dose of the study drug.
• Women who are not able to become pregnant due to reasons such as being postmenopausal for over 2 years, having had certain surgical procedures, or meeting other defined criteria (confirm with trial site).
• People who have read, or had explained to them, the study's purpose and have signed a consent form before joining. Non-English speakers may be consented according to the institution's own procedures.

Who may not be able to join:

• People with a history of autoimmune conditions, with the exception of certain conditions including alopecia (hair loss), vitiligo, rheumatoid arthritis, psoriasis or psoriatic arthritis, and Hashimoto's thyroiditis, which are permitted.
• People currently taking immunosuppressive medications, including steroids at a dose higher than the equivalent of 10 mg of prednisone daily (short courses of steroids that are stopped before treatment begins may be acceptable).
• People with significant heart, liver, or kidney disease that their treating doctor considers would make chemotherapy or immunotherapy unsafe for them.
• People who are currently participating in another clinical trial involving an experimental treatment.
• Women who are currently pregnant or breastfeeding.
• People with any other medical or psychiatric condition that their doctor considers makes participation in this trial unsuitable.
• People who have brain metastases that are causing symptoms and have not yet been treated. People whose brain metastases have been treated with radiation may be considered if steroid doses have been reduced below the equivalent of 10 mg of prednisone daily.
• People who have an active infection currently being treated with intravenous (IV) antibiotics.

Important: Always verify eligibility with the trial site directly before applying.