Phase 2 Kidney Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with clear cell renal (kidney) cancer, confirmed by a tissue sample (other cancer cell types mixed in are allowed)
• People whose cancer is rated as "good" or "intermediate" risk based on a scoring system called Heng criteria (confirm with trial site)
• People who have cancer that has spread to areas outside the brain, confirmed by scans
• People who are currently receiving, or have received, either their first or second course of systemic (whole-body) cancer treatment
• People whose systemic treatment has been a targeted therapy or immunotherapy that meets current French medical standards, or people who were in another clinical trial if that trial's sponsor permits participation
• People whose cancer has started growing again in only 1 to 3 spots, spread across no more than 2 organs (called "oligoprogressive disease"), confirmed by scans
• People whose limited progression has been confirmed by two scans taken approximately 2 months apart
• People who have at least one measurable growing tumour spot, assessed using standard imaging measurements (RECIST v1.1)
• People whose growing tumour spots each measure 4 cm (about 1.5 inches) or smaller
• People who are in reasonably good general health, rated 0, 1, or 2 on the WHO performance scale (confirm with trial site)
• People whose growing tumour spots can all be treated with a type of precise radiation called stereotactic radiotherapy (SRT), either at the same time or one after another
• People who have no medical reasons preventing them from receiving systemic therapy and stereotactic radiotherapy
• People aged 18 years or older
• People who have signed a consent form agreeing to take part
• People who are enrolled in the French social security system

Who may not be able to join:

• People who have more than 3 spots where the cancer is actively growing
• People whose cancer cannot be measured using standard imaging criteria
• People who have already had 3 or more separate courses of systemic (whole-body) cancer treatment
• People whose growing tumour spots cannot all be treated with stereotactic radiotherapy
• People who have previously had radiation treatment to any of the tumour spots being targeted in this trial
• People who have at least one growing tumour spot measuring larger than 4 cm
• People who have cancer that has spread to the brain
• People who have a tumour in a very central part of the lung (confirm with trial site on exact definition)
• People who have a growing tumour spot in a long bone (such as the arm or leg bones)
• People who have at least one growing tumour spot that would require surgery to treat
• People who have been diagnosed with another type of cancer within the last 5 years
• People who are pregnant, breastfeeding, or not using adequate contraception
• People who would not be able to attend follow-up appointments as required by the trial
• People who are legally detained or under a guardianship arrangement

Important: Always verify eligibility with the trial site directly before applying.