Phase 3 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been newly diagnosed with a type of blood cancer called acute lymphoblastic leukaemia (ALL) — either T-cell ALL or B-cell precursor ALL — confirmed by an approved laboratory.
• You are between 0 and 45 years old at the time of diagnosis (with a specific exception for very young infants with a particular genetic change — confirm with trial site).
• Your leukaemia has specific genetic features: certain patients with a gene change called IG::MYC (without certain other gene changes), or T-ALL patients with a MYC gene change (confirm with trial site for your specific situation).
• You (and/or your parents or legal guardians, if you are a child) have signed a consent form agreeing to take part.
• You are being diagnosed and treated at a hospital that is taking part in this trial.
• You live permanently in one of the countries taking part in the trial, or you plan to stay there (for example, if you are applying for asylum).
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 2 weeks before starting treatment.
• There may be additional requirements depending on which specific part of the trial you are being considered for (confirm with trial site).

Who may not be able to join:

• Babies under 1 year old who have a specific genetic change called KMT2A-rearrangement in their leukaemia.
• Anyone aged 46 or older at the time of diagnosis.
• Anyone who has previously had another cancer diagnosis.
• Anyone whose ALL has already come back (relapsed).
• Patients with a specific type called "mature B-ALL," or those with certain combined gene changes (IG::MYC together with BCL2/6 rearrangement).
• Patients whose leukaemia has a gene change called Philadelphia chromosome (Ph-positive ALL) — these patients may be directed to a different, more suitable trial.
• People who were already known to have certain inherited conditions that increase the risk of ALL (such as Li-Fraumeni syndrome or germline ETV6 mutation) — though Down syndrome is an exception and does not exclude you.
• Anyone who received steroid medicines above a certain dose for more than one week, or any chemotherapy, in the four weeks before diagnosis.
• Anyone who has a pre-existing health condition that would prevent them from safely receiving the treatments used in this trial.
• Anyone with another illness or condition that the doctor believes would make it unsafe or impractical to take part.
• Women who are pregnant at the time of diagnosis.
• Women who could become pregnant, or men who could father a child, who are sexually active but unwilling to use effective contraception during treatment.
• Women who are currently breastfeeding.
• Cases where important information needed at the time of registration is missing (confirm with trial site).
• There may be additional reasons specific to certain parts of the trial that could affect eligibility (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.