Phase 3 Endometriosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are a woman between 18 and 35 years old (inclusive) who has been diagnosed with endometriosis and/or adenomyosis
• You have already gone through IVF (in vitro fertilisation) or ICSI (a type of IVF where a single sperm is injected into an egg), where all embryos were frozen, and a planned transfer of a frozen embryo at the blastocyst stage is coming up
• You have a normal uterine cavity (the inside of your womb has no abnormalities)
• You have had an MRI scan that confirms endometriosis and/or adenomyosis at the time of joining the trial
• You have signed a consent form agreeing to take part
• You are covered by a health insurance plan

Who may not be able to join:

• You are under 18 or 36 years of age or older
• Your Body Mass Index (BMI) is over 35
• You have had 2 or more previous failed embryo implantation attempts
• You have certain changes or growths inside your womb, such as scar tissue, polyps, fibroids, abnormal thickening of the womb lining, or a build-up of blood in the womb
• You have a known blockage or fluid build-up in one or both fallopian tubes (known as hydrosalpinx)
• Your MRI scan does not show signs of endometriosis or adenomyosis
• You have a known allergy or sensitivity to any of the medications used in this trial, including: GnRH or similar hormone medicines (such as Decapeptyl), oestrogen (estradiol), progesterone, aspirin or anti-inflammatory painkillers (NSAIDs), folic acid, the antibiotics cefixime (or similar cephalosporin antibiotics), or levofloxacin (or similar quinolone antibiotics)
• You have a history of tendon problems caused by a type of antibiotic called fluoroquinolones
• You have epilepsy
• You have a known allergy to MRI contrast dye
• You have been diagnosed with, or are suspected to have, breast cancer — or have a history of breast cancer
• You have been diagnosed with, or are suspected to have, cancer of the reproductive organs — or have a history of such cancer
• You have any cancer that is known or suspected to be worsened by oestrogen
• You have unexplained vaginal bleeding that has not been investigated
• You have untreated abnormal thickening of the womb lining (endometrial hyperplasia)
• You have a history of blood clots in the veins (such as deep vein thrombosis or pulmonary embolism), or currently have one
• You have recently had or currently have a blood clot affecting arteries, such as a heart attack or stroke
• You have an active liver disease, or a history of liver disease where liver test results have not returned to normal
• You have severe kidney disease
• You have severe heart failure that is not well controlled
• You currently have an active stomach or duodenal ulcer
• You have a history of asthma triggered by aspirin or similar anti-inflammatory medicines
• You have received the hormone treatment Decapeptyl (a GnRH agonist) within the 6 months before your planned embryo transfer
• You are currently pregnant or breastfeeding
• You are under legal guardianship or have restrictions on your personal freedom (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.