Endometrial Cancer Trial, Recruiting NCT04362046 Sponsor: Vancouver Coastal Health Research Institute Condition: Endometrial Cancer
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Endometrial Cancer Trial, Recruiting

NCT04362046
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who are under 40 years of age
  • People who have received a confirmed tissue biopsy diagnosis of either: (a) early-stage (Grade 1) uterine cancer affecting less than one-third of the uterine lining, or (b) atypical endometrial hyperplasia (an abnormal but non-cancerous thickening of the uterine lining)
  • People whose MRI scan shows that any uterine cancer has not grown more than one-third of the way into the uterine wall muscle
  • People who do not have serious health conditions that would make surgery unsafe, such as severe heart or lung conditions
  • People who wish to preserve their ability to have children in the future
  • People assessed by a fertility specialist as having a reasonable chance of becoming pregnant
  • People who have already tried hormone therapy (specifically, medroxyprogesterone acetate at 200mg/day or megestrol acetate at 160mg/day) for at least 6 months before entering the trial
  • People for whom hormone therapy either did not fully clear the abnormal cells, or who were unable to tolerate the side effects of that therapy
  • People who have provided signed consent to participate in the trial

Who may not be able to join:

  • People who are 40 years of age or older
  • People whose uterine cancer is Grade 2 or Grade 3, or is a type other than endometrioid
  • People with Grade 1 uterine cancer where more than one-third of the uterine lining is affected
  • People who are not able to give informed consent to participate
  • People who do not have a confirmed tissue biopsy diagnosis of the required condition
  • People whose MRI scan shows the cancer has grown more than one-third of the way into the uterine wall muscle
  • People whose MRI scan shows involvement of the ovaries or surrounding structures
  • People who have another cancer or serious medical condition that could affect how well the trial results can be assessed
  • People with significant underlying fertility problems that could interfere with the success of the surgical procedure

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 27 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Mark Carey, MD, Vancouver Coastal Health

Phone: 604-875-5508

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Sponsor
Vancouver Coastal Health Research Institute
Registry
ClinicalTrials.gov
Start date
15 November 2020
Est. completion
1 July 2028

Where this trial is recruiting

🇨🇦 Canada

Primary endpoints

Conception rate of women attempting pregnancy; Overall conception rate; Local disease control rate (short-term failure of hysteroscopic resection); Distant disease control rate (long-term failure of hysteroscopic resection)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov