Phase 1 Bladder Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a specific type of cancer that has spread or cannot be surgically removed, confirmed by a lab test — eligible cancer types include non-small cell lung cancer, head and neck squamous cell cancer, HER2-negative breast cancer, esophageal squamous cell carcinoma, esophageal/gastro-esophageal junction adenocarcinoma, cutaneous squamous cell cancer, pancreatic cancer, bladder cancer, cervical cancer, gastric (stomach) cancer, or high-grade serous ovarian cancer.
• Depending on which part of the trial you join, your cancer has come back or stopped responding to standard treatments, or you were unable to tolerate them (confirm with trial site for specific part requirements).
• For some parts of the trial, you must be starting treatment for your advanced or spread cancer for the first time (no prior treatment for this stage of disease).
• You are well enough to carry out basic daily activities, with only mild limitations at most (a doctor's assessment score of 0 or 1 on a standard scale).
• Your cancer can be measured using scans at the start of the study.
• Depending on which part of the trial you join, you may need to agree to have a small sample of your tumor taken (a biopsy) before and/or during treatment.

Who may not be able to join:

• You have had another type of cancer within the past 3 years, or there are still signs of a previous cancer in your body (with some exceptions for low-risk cancers — confirm with trial site).
• You currently have active cancer that has spread to your brain; however, if brain spread was previously treated and has been stable for at least 4 weeks, you may still be eligible (confirm with trial site).
• Cancer has spread to the membranes surrounding your brain or spinal cord.
• You have previously received a specific type of drug called an MMAE-containing agent, or a drug that targets a protein called integrin beta-6.
• You already have nerve damage (such as tingling, numbness, or pain in hands or feet) — the level of nerve damage that disqualifies you depends on which part of the trial you are joining (confirm with trial site).
• You have had a serious uncontrolled infection (viral, bacterial, or fungal) in the 2 weeks before starting the study drug.
• You have severe lung disease that is not caused by your cancer.
• For some parts of the trial: you previously received certain immune-based cancer treatments and had to stop because of a serious immune-related side effect (grade 3 or higher).
• You have a history of a non-infectious lung condition called interstitial lung disease (ILD) or pneumonitis that needed steroid treatment, or you currently have or are suspected to have this condition.
• Your lungs' ability to absorb oxygen is significantly reduced (below 50% of the expected level on a specific breathing test — confirm with trial site).
• You or your close family members work directly on this trial at the study site or for the company running the trial.

Important: Always verify eligibility with the trial site directly before applying.