Phase 2 Tuberculosis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- Adults aged over 18 years
- People with suspected tuberculosis of the sac around the heart (pericardium), with fluid around the heart confirmed by an ultrasound scan (echocardiogram)
- People who agree to take part in the study, including agreeing to an HIV test if their HIV status is not already known
- People where tuberculosis bacteria have been found in the fluid around the heart, or where tuberculosis of the pericardium is considered probable based on specific medical criteria — either tuberculosis confirmed elsewhere in the body alongside signs of pericarditis, or certain characteristics of the pericardial fluid (confirm with trial site for full details)
- People who are scheduled to have a procedure to drain the fluid from around the heart (pericardiocentesis), based on their clinical need
- People who are within 5 days of starting tuberculosis drug treatment
Who may not be able to join:
- People whose kidneys are not working well enough (low filtration rate under 30ml/min) or who need dialysis
- People whose tuberculosis is resistant to the drug Rifampin
- People with a serious additional infection occurring at the same time
- People for whom placing a drainage tube into the sac around the heart is not medically appropriate
- People in whom the fluid drainage procedure or placement of the drainage tube was not successful
- People who have a medical reason they cannot take standard tuberculosis medications, including any known allergy to these drugs or their ingredients
- Women who have a positive pregnancy test
- People with a confirmed autoimmune condition, such as lupus
Additional criteria that apply to a specific heart scan (MRI with contrast dye) part of the trial — people may not be eligible for this part if they:
- Have any implanted medical devices that are not safe to use near an MRI machine (such as pacemakers, defibrillators, certain brain aneurysm clips, or cochlear implants)
- Experience severe anxiety in enclosed spaces (claustrophobia)
- Have a known allergy to the MRI contrast dye (gadolinium)
- Are unable to lie flat and still for an extended period (for example, due to severe heart failure)
- Are currently breastfeeding
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Mpiko U Ntsekhe, Professor, Department of Cardiology, Groote Schuur Hospital
Phone: 0727633386
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Drug exposure in PCF and mediates in Mtb load
Can't join this trial?
Data last synced from ClinicalTrials.gov: 15 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.