Phase 4 Chronic Kidney Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 years or older.
• People with advanced chronic kidney disease (stage 4 or 5, including those on dialysis), meaning the kidneys are working at 29% or less of normal function.
• People whose bone density scan (DXA) shows significantly low bone density at the hip or spine, meeting specific score thresholds — or who have previously had a fragility fracture (such as a fracture of the spine, hip, forearm, upper arm, or ankle) confirmed by scan or X-ray. (The exact score thresholds differ for people taking prednisolone tablets long-term — confirm with trial site.)
• People whose bone activity blood tests or bone biopsy results suggest a condition called "adynamic bone disorder," where the bones are not renewing themselves as actively as normal.

Who may not be able to join:

• People with persistently high calcium levels in their blood.
• People who have had a fracture in the last 6 months (re-screening may be possible after 6 months — confirm with trial site).
• People who have previously had a condition called calciphylaxis (a serious condition involving calcium deposits in blood vessels).
• People with thyroid problems that have not been adequately treated, in the opinion of their doctor (re-screening may be possible after treatment — confirm with trial site).
• People currently taking a heart medication called digoxin.
• People with Paget's disease or other conditions affecting bone metabolism.
• People who have used certain bone-strengthening medications in the last 24 months, or specific medications called bisphosphonates in the last 12 months.
• People with a current or past cancer diagnosis, except for certain types of non-melanoma skin cancer.
• People who have had radiation therapy to any part of the skeleton.
• People who have received a kidney transplant within the last 12 months.
• People with low vitamin D levels in their blood (re-screening may be possible after levels are corrected — confirm with trial site).
• People who are unable to use the teriparatide injection device.
• People with significantly reduced liver function, based on specific blood test results.
• People who are pregnant, breastfeeding, or are women of childbearing potential who are not using an approved form of contraception (such as an intrauterine device, or hormonal contraception including pills, implant, patch, vaginal ring, or injection).
• People with a known allergy or sensitivity to teriparatide or any of its ingredients.
• People who are unable to give informed consent.
• People with other medical conditions or treatments that may interfere with the trial's results.
• People with a history of drug or alcohol misuse.
• People whom the local trial investigator considers unable to participate in a clinical study.
• For people taking part in the optional bone biopsy procedure: those with an allergy to tetracycline antibiotics; those on blood-thinning medications that cannot be safely paused; or those with bleeding or clotting disorders.
• For people taking part in optional pulse wave measurements: those with a heart rhythm condition called atrial fibrillation, or those with a heart valve condition called aortic stenosis.

Important: Always verify eligibility with the trial site directly before applying.