Endometrial Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People whose cervical cancer has been confirmed by a pathology test to be one of these types: squamous cell carcinoma, adenocarcinoma, or adeno-squamous cell carcinoma
• People diagnosed with stage IIICr cervical cancer, confirmed by a CT, MRI, or PET/CT scan, where at least one affected lymph node measures 15mm or more across its shortest width on imaging
• People with a general health score of 0 or 1 on a standard medical scale (meaning fully active or able to carry out light work), known as an ECOG score
• People whose doctors expect them to live for more than 6 months
• Women of childbearing age whose pregnancy test (blood or urine) is negative within 7 days before enrolling, and who agree to use contraception throughout the trial
• People who have no medical reasons that would make surgery unsafe for them

Who may not be able to join:

• People with an active or uncontrolled serious infection
• People with active hepatitis B, liver cirrhosis, or severely reduced liver function
• People with a history of immune system deficiency, including HIV-positive status or other conditions that weaken the immune system
• People with an active autoimmune disease that currently requires ongoing treatment with immune-suppressing or disease-modifying medications (note: hormone replacement treatments such as thyroid medication, insulin, or low-dose steroids for adrenal or pituitary conditions are not counted as exclusions under this criterion — confirm with trial site)
• People who have previously had lung inflammation (pneumonitis) that required steroid treatment, or who currently have pneumonitis
• People with chronic kidney insufficiency or kidney failure
• People who have been diagnosed with another cancer within the past 5 years and/or who have required treatment for another cancer
• People with a history of heart attack, serious irregular heartbeat, or moderate-to-severe heart failure (classified as NYHA grade 2 or higher)
• People who have received a transplant of donor tissue or a solid organ
• People who have previously had a pelvic artery embolization procedure
• People who have previously had radiation therapy to the pelvic area
• People who have had a partial or full surgical removal of the uterus (hysterectomy)
• People who have previously received immunotherapy or who are currently receiving immunotherapy
• People with a known history of severe allergic reactions to platinum-based chemotherapy drugs, pembrolizumab, or any of their ingredients
• People who need to take medications during the trial that can cause serious liver or kidney damage — for example, certain treatments for tuberculosis (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.