Phase 2 PTSD Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who have a current diagnosis of PTSD where the traumatic event involved physical or sexual assault
- People who speak English
- People who are in general good health
Who may not be able to join:
- People who have metal objects inside their body, such as surgical implants, shrapnel, screws, pins, aneurysm clips, artificial heart valves, cochlear (inner ear) implants, artificial joints, or vascular stents, as these can be affected by the MRI scanner's strong magnetic field
- People who have electronic or magnetic implants, such as a pacemaker, as these may stop working near an MRI scanner
- People who have permanent makeup or tattoos made with metallic dyes
- People who have a serious medical condition such as cancer or HIV
- People who have a psychotic disorder, such as schizophrenia
- People who have a neurocognitive disorder (confirm with trial site)
- People who have a developmental disorder (confirm with trial site)
- People who are currently pregnant or who test positive on a pregnancy test on the day of the MRI scan (female participants of childbearing age will be tested on that day and notified of results)
- People who are currently breastfeeding
- People who have taken a type of medication called MAO inhibitors (MAO-I) within the past two weeks
- People who have claustrophobia or are unable to lie still in a confined space
- People who have a history of losing consciousness for more than 30 minutes
- People who have a physical disability that would prevent them from completing tasks, such as blindness or deafness
- People at the University of Texas Austin site who have heart disease, liver problems, peptic ulcer disease, or a chronic lung condition called COPD
- People at the University of Texas Austin site who are taking prescription medications that may interact with the study drug L-DOPA (a wash-out period may apply — confirm with trial site)
- People taking medications that may affect MRI image quality, such as water pills (at the investigator's discretion)
- People with non-removable dental implants such as braces or permanent retainers, as these can distort MRI images (at the investigator's discretion; fillings, crowns, and gold or silver teeth are generally acceptable)
- People with any other condition, medication, or implant that the investigator believes could affect safety or the quality of the data collected
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Zachary Stowe, MD, University of Wisconsin, Madison
Phone: 608-262-6375
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in negative emotional responding to trauma scripts on Day 2 compared to Day 1
Can't join this trial?
Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.