Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 8 or older who have been diagnosed with Cushing's disease based on medical records, with lab results confirming the condition
• People whose MRI of the pituitary gland either showed no tumor or only a possible tumor (not a confirmed tumor)
• People who had an MRI of the pituitary gland, with and without contrast dye, within the past 9 months
• People newly diagnosed with Cushing's disease who have had a specific blood sampling procedure from veins near the pituitary gland (called IPSS) performed
• People who are able to have a PET scan while awake, without needing general anesthesia
• People who are able to give informed consent to take part — or, in the case of children, whose parent or guardian is able to give consent on their behalf
• People who are willing and medically suitable to have surgery to remove an ACTH-producing pituitary tumor within 24 weeks of the PET scan
• People with normal liver function, confirmed by blood tests taken within 14 days before the scan
• People who have previously tolerated a medication called DDAVP without problems (including as part of their Cushing's disease diagnosis process)

Who may not be able to join:

• People who are currently pregnant or breastfeeding
• People with significantly reduced kidney function, a combined liver and kidney condition (hepatorenal syndrome), a history of difficulty passing urine, or who have previously had a liver or kidney transplant
• People with low sodium levels in their blood (below a certain threshold)
• People currently diagnosed with chest pain (angina), significant heart artery disease, heart failure, or a condition called SIADH (a hormone condition that causes the body to retain too much water)
• People with uncontrolled high blood pressure above a certain level
• People with severe or symptomatic low blood pressure
• People currently taking certain medications, including:
  • Blood pressure-supporting drugs such as phenylephrine, dopamine, or vasopressin
  • Certain medications that can lower sodium levels, including some anti-inflammatory painkillers (NSAIDs, within 4 days of testing), certain water tablets (loop diuretics), chlorpromazine, chlorpropamide, cisplatin, certain strong pain medications (opiate-based, within 48 hours of testing), or vincristine
  • Certain medications that affect how DDAVP works in the body, including carbamazepine, lamotrigine, or tolvaptan
• People with a condition causing excessive thirst and fluid intake (habitual or psychogenic polydipsia)
• People with a history of a specific blood clotting disorder called Type IIB von Willebrand's disease
• People with a blood sugar level above a certain level on the day of the scan, before the scan begins
• People with a known intolerance or allergic reaction to DDAVP
• Children under the age of 8, as PET scans at that age typically require general anesthesia, which carries greater risk
• Women who are able to become pregnant and return a positive pregnancy test within 24 hours before the PET scan

Important: Always verify eligibility with the trial site directly before applying.