Phase 2 Melanoma Trial, Recruiting NCT04594187 Sponsor: M.D. Anderson Cancer Center Condition: Melanoma
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Phase 2 Melanoma Trial, Recruiting

NCT04594187
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who are planned to receive immunotherapy after surgery
  • People who have no signs of cancer that has spread to distant parts of the body, based on physical examination and imaging scans
  • People who had no signs of cancer in their lymph nodes before a sentinel lymph node biopsy (a procedure to check nearby lymph nodes)
  • People whose sentinel lymph node biopsy confirmed melanoma with at least one high-risk feature — such as cancer breaking through the lymph node's outer layer, a tumour deposit of 0.5mm or larger in the node, two or more affected lymph nodes, or cancer found in blood or lymph vessels near the original tumour
  • People who have provided written consent to take part in the trial
  • People with a general health and activity level rated 3 or below on a standard medical scale (meaning some self-care may be limited but the person is not completely unable to care for themselves — confirm with trial site)
  • People with a life expectancy of more than 6 months
  • People who are capable of becoming pregnant and are using adequate contraception
  • People who are able to attend follow-up appointments

Who may not be able to join:

  • People who have had a full removal of all lymph nodes in the affected area (complete lymph node dissection)
  • People whose cancer has already spread to distant parts of the body
  • People who have previously had radiation therapy to the same lymph node area being considered for treatment in this trial, where the new treatment would overlap with tissue that was already irradiated
  • People who are currently pregnant
  • People who are unable to provide their own informed consent, anyone under the age of adulthood, pregnant women, and prisoners

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 14 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Devarati Mitra, M.D. Anderson Cancer Center

Phone: 713-563-1339

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Registry
ClinicalTrials.gov
Start date
26 August 2021
Est. completion
31 December 2027

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Time to regional nodal recurrence

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 14 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov