Phase 2 Lung Cancer Trial, Recruiting NCT04691817 Sponsor: Abramson Cancer Center at Penn Medicine Condition: Lung Cancer
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Phase 2 Lung Cancer Trial, Recruiting

NCT04691817
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • Adults aged 18 or older who have been diagnosed with advanced non-squamous non-small cell lung cancer (a specific type of lung cancer) that is either at Stage IV or has come back after earlier treatment that was intended to cure it
  • People who have already received at least one round of cancer treatment before enrolling
  • People whose most recent treatment before joining the trial included a type of drug called a checkpoint inhibitor (a form of immunotherapy)
  • People whose general physical functioning is rated at a certain level, meaning they are able to care for themselves and are not completely disabled (confirm with trial site)

Who may not be able to join:

  • People whose lung cancer has a specific genetic change (called a driver mutation) that can be targeted by specialised drugs
  • People who experienced severe side effects (grade 3 or higher on a standard medical scale) from previous immunotherapy treatment
  • People who have another active, unrelated cancer that currently requires treatment
  • People who have brain metastases (cancer that has spread to the brain) that are growing or have not yet been treated
  • People who have cancer that has spread to the lining around the brain or spinal cord, either currently or in the past
  • People who have pain caused by their tumour that is not well controlled
  • People with a history of an autoimmune disease (where the immune system attacks the body) or a lung condition called idiopathic pulmonary fibrosis (IPF)

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 19 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Melina Marmarelis, MD, MSCE, Abramson Cancer Center at Penn Medicine

Phone: 215-220-9703

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
Abramson Cancer Center at Penn Medicine
Registry
ClinicalTrials.gov
Start date
25 July 2023
Est. completion
1 December 2026

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Overall response rate (ORR)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 19 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov