Tuberculosis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 18 and 60 years old.
- You are willing to have a chest X-ray and/or CT scan.
- You have TB affecting only one lung (this requirement does not apply to healthy participants joining as controls; participants joining as "sick controls" will need a different diagnosis).
- You have not had TB treatment before, and your chest X-ray or CT scan does not show signs of previous TB.
- You are willing to have a research bronchoscopy (a procedure to look inside the airways) at the start of the study, at 6 months, and at 18 months, and you expect to stay in the local area for the full study period.
- If you are HIV-positive, you have been stable on HIV treatment (ART) for at least one year.
- You are able and willing to come back for follow-up visits and do not plan to move away in the near future.
- You are willing to follow all study requirements, including providing your contact details and signing a consent form before joining.
Who may not be able to join:
- You are younger than 18 or older than 60 years of age.
- You have already started TB treatment.
- Your TB is resistant to the antibiotic Rifampicin.
- You have had TB in the past.
- You have TB affecting both lungs extensively.
- You have taken probiotics, antibiotics, or inhaled steroids within the last three months (this does not apply to "sick control" participants).
- You have diabetes.
- You have a medical reason why a bronchoscopy (airway examination procedure) would not be safe for you, as decided by the medical team (confirm with trial site).
- You drink more than 6 beers or 4 mixed drinks every day.
- You are currently pregnant or plan to become pregnant during the follow-up period (a urine pregnancy test will be carried out).
- You have been hospitalised recently for any reason.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Grant Theron, PhD, University of Stellenbosch
Phone: (+27) 021 938 9693
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Characterization of changes in microbiota in diseased vs. non-diseased lung segments, stratified by HIV status.; Association of specific microbial taxa in diseased segments with elevated SCFAs and impaired host inflammation and tissue repair biomarkers.; Evaluate the impact of treatment on the lung microbiome.
Can't join this trial?
Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.