Phase 2 Melanoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have one of the following cancers: melanoma of the skin or mucous membranes (that cannot be surgically removed or has spread) and no standard treatments are left; melanoma of the eye (uveal melanoma) that has spread and has gotten worse after standard treatment; or head and neck squamous cell cancer that has spread or come back and no standard treatments are left
• You have a specific genetic marker called HLA-A2*0201 (a blood test can determine this)
• Your tumor tissue (from a previous or new biopsy) tests positive for a protein called MC2 in more than 5% of the tumor cells
• Your cancer can be measured on scans according to standard medical guidelines
• You have at least one tumor that can be safely biopsied more than once during the study
• You are in generally good physical condition and able to carry out daily activities with little or no limitation (confirm with trial site), and your doctor expects you to live at least 12 weeks
• Your melanoma has shown clear signs of getting worse during or after standard treatments, and your last treatment was finished more than 4 weeks ago (or at least 2 weeks ago if you were on certain targeted therapy drugs called BRAF and MEK inhibitors)
• If you have head and neck cancer, your disease has gotten worse and you are either unable or unwilling to receive platinum-based chemotherapy, or no standard treatments are available
• You are willing to use a highly effective form of birth control during the treatment and for four months afterward (applies to all genders)
• Your blood test results at screening meet specific minimum levels for blood cell counts, liver function, kidney function, and bilirubin without the help of growth factor injections or blood transfusions (confirm specific values with trial site)
• Your blood tests show you are negative for HIV, hepatitis B, hepatitis C, and syphilis

Who may not be able to join:

• You currently have brain metastases (cancer that has spread to the brain) causing symptoms — though if those brain lesions have already been treated with radiation or surgery and are now stable, you may still be eligible (confirm with trial site)
• You have new or actively growing cancer in the brain at the time of joining the study — though stable or previously treated brain metastases may be acceptable (confirm with trial site)
• Cancer has spread to the lining around the brain or spinal cord
• You have a build-up of fluid caused by cancer in the lining of the lungs or abdomen
• You are taking steroid tablets at a dose higher than 10 mg of prednisone per day (or an equivalent) or other medicines that suppress the immune system within a certain time period before treatment — though steroid creams, inhalers, nasal sprays, or eye drops are generally allowed (confirm with trial site)
• You have an active autoimmune disease (where the immune system attacks the body) or a documented history of one — though certain mild or well-controlled conditions like vitiligo, stable type 1 diabetes, treated low thyroid function, or mild psoriasis not needing systemic treatment may be acceptable (confirm with trial site)
• You have any active serious infections, blood clotting disorders, or other major active health conditions
• You have had a heart attack, heart procedure, unstable chest pain, or other significant heart disease within the past 6 months
• You still have significant side effects from previous cancer treatments that have not improved to a mild level
• You are pregnant or breastfeeding; a negative pregnancy test is required before joining for all women who could become pregnant
• You have received a live vaccine (for example, for an infectious disease) within the last 3 months
• You currently have an active infection that requires antibiotic treatment taken by mouth or by IV
• You have previously had a bone marrow transplant from a donor or a transplant of a solid organ (such as a kidney or liver)
• You have a known allergy to any of the drugs used in this study
• You have another active cancer — though cancers that were fully treated and have not come back within the last 2 years, certain fully removed skin cancers, or fully removed early-stage cancers (carcinoma in situ) may be exceptions (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.