Phase 3 Head and Neck Cancer Trial, Recruiting NCT04778956 Sponsor: Sun Yat-sen University Condition: Head and Neck Cancer
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Phase 3 Head and Neck Cancer Trial, Recruiting

NCT04778956
Recruiting Phase 3

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • The cancer came back more than 6 months after finishing radiation treatment.
  • A tissue biopsy has confirmed that the cancer is a recurrent (returned) nasopharyngeal carcinoma (a type of cancer in the back of the nose/throat area).
  • The tumor in the nasopharynx area is at a stage considered surgically removable, meaning it has not spread too close to certain major blood vessels or surrounding structures (confirm exact staging details with the trial site).
  • Any cancer that has returned in the lymph nodes of the neck is also considered surgically removable, and has not grown into the spine-area lining, neck vertebrae, or major neck arteries (confirm with trial site).
  • The person has provided written agreement to participate in the trial.

Who may not be able to join:

  • People whose general health and ability to carry out daily activities falls below a certain level on a standard medical scoring scale (confirm specific threshold with trial site).
  • People with serious medical conditions, major problems with how key organs are functioning, or a significant history of mental illness.
  • People who have another type of cancer (in addition to nasopharyngeal carcinoma).
  • People who have taken part in another drug trial within the 3 months before the planned start of this study.
  • People who have received steroid medications (glucocorticoids) either throughout the body or in a specific area within the 4 weeks before the planned start of this study.
  • People who have a condition that requires long-term use of immune-suppressing medications, or who need ongoing steroid treatment at immune-suppressing doses.
  • People who have previously been treated with certain types of immunotherapy drugs that target PD-1, PD-L1, or CTLA-4 pathways.
  • People who have an active autoimmune disease (where the immune system attacks the body's own tissues), such as certain conditions affecting the eyes, gut, liver, kidneys, blood vessels, or thyroid — though some skin conditions that do not require full-body treatment may still be eligible (confirm with trial site).
  • People who have a known history of HIV infection, a certain level of active hepatitis B virus in the blood, or a positive test for hepatitis C antibodies.
  • People who have received a live vaccine within the 4 weeks before the planned start of this study.
  • People who are pregnant or currently breastfeeding.
  • People who would not be able to attend regular follow-up appointments as required by the trial.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 20 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Ming-Yuan Chen, MD, PhD, Sun Yat-sen University

Phone: 86-20-87343624

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Registry
ClinicalTrials.gov
Start date
3 March 2021
Est. completion
3 March 2025

Where this trial is recruiting

🇨🇳 China

Primary endpoints

Disease-free survival

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 20 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov