Phase 3 Non-Alcoholic Fatty Liver Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- Women who have gone through menopause and are between 45 and 70 years old
- People who have been diagnosed with a specific type of liver disease called NASH (confirmed by a liver tissue sample) or a related condition called NAFLD (confirmed by a medical scan) within the past 6 months
- People whose blood tests show no signs of Hepatitis B or Hepatitis C infection
- People who have had a clear mammogram (breast screening) within the past year
Who may not be able to join:
- People who drink alcohol heavily
- People who have used medications specifically to treat NASH in the past 12 months
- People who have been diagnosed with cirrhosis (severe liver scarring), have advanced scarring shown on a liver tissue sample, or show signs of serious liver damage on scans or physical examination
- People who have taken part in another NASH clinical trial within the past 6 months
- People who have regularly used certain medications — including corticosteroids (steroid medicines), methotrexate, amiodarone, or tamoxifen — within the past 6 months
- People who have a known liver disease other than NAFLD, or where a liver tissue sample shows a different liver condition
- People for whom a liver biopsy (tissue sample procedure) would not be safe — for example, due to certain blood clotting results, low platelet counts, fluid in the abdomen, ongoing blood-thinning medication (other than aspirin), bile duct blockage, abdominal infection, or inability to lie flat for 30 minutes (confirm with trial site)
- People with low haemoglobin (a measure of red blood cells) or reduced kidney function below certain levels (confirm with trial site)
- People for whom oestrogen therapy is medically unsuitable
- People who have had any vaginal bleeding or spotting within the past year
- People with an active cancer diagnosis
- People with a severe ongoing illness
- People who have used oestrogen or progesterone (hormone treatments) within the past year
- People who cannot have an MRI scan — for example, those with a pacemaker or a surgical clip for a brain aneurysm
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Karen K. Miller, MD, Massachsuetts General Hospital
Phone: 617-643-8635
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Liver fat
Can't join this trial?
Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.