Non-Alcoholic Fatty Liver Disease

Clinical trials recruiting in Australia for Non-Alcoholic Fatty Liver Disease, as the public registries list them.

Also called: ALD; Alcohol-associated liver disease; Alcoholic fatty liver disease; Fatty Liver Disease; MASLD; Metabolic dysfunction-associated steatotic liver disease; NAFLD; Nonalcoholic fatty liver disease; SLD; Non-alcoholic steatohepatitis

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Sources: ClinicalTrials.gov, MedlinePlus Checked: 15 October 2026 Not medical advice

At a glance

13 trials recruiting in Australia

5 states or territories with a listed site

0 started recruiting in the last 30 days

301 trials recruiting overseas

15 October 2026 date last checked

Where the trials are

Listed sites in each state and territory. Choose one to show only the trials with a site there, and choose it again to show them all.

5 listed sites on this page do not say which state they are in, so the counts above are lower than the real number of sites in some states. The trials themselves are all listed below.

Trials not shown here

Some Australian trials are registered only on the Australian New Zealand Clinical Trials Registry and are not shown here. Search them at Australian Clinical Trials.

Trials overseas

301 trials for this condition are open to new participants outside Australia, as ClinicalTrials.gov listed them on 11 October 2026. Voxsanity does not publish a page for any of them; the searches below reach them at the registry.

These overseas counts are likely too high. They come from the registry’s own search, which expands a condition name to related conditions, so some of the trials counted are for a different disease in the same family.

Search ClinicalTrials.gov Search the WHO registry portal Joining a trial overseas

About Non-Alcoholic Fatty Liver Disease

The text below is reproduced exactly as its source published it. It has not been edited, shortened or rewritten.

What is steatotic liver disease? Your liver is the largest organ inside your body. It helps you digest food, store energy, and remove harmful substances (toxins). Steatotic liver disease, formerly called fatty liver disease, happens when too much fat builds up in your liver. It's typical to have some fat in your liver cells, but too much can be a problem. There are two main types of steatotic liver disease: - Metabolic dysfunction-associated steatotic liver disease (MASLD) - Alcohol-associated liver disease (ALD) What is metabolic dysfunction-associated steatotic liver disease (MASLD)? MASLD is a type of steatotic liver disease that is not caused by heavy alcohol use. It used to be called nonalcoholic fatty liver disease. There are two main forms: - Simple fatty liver, in which you have fat in your liver but little or no inflammation or liver damage. This form usually does not get bad enough to cause liver damage or complications. - Metabolic dysfunction-associated steatohepatitis, or MASH (previously called nonalcoholic steatohepatitis or NASH), is when MASLD gets worse. In addition to fat in your liver, MASH may cause inflammation and liver damage. This can lead to fibrosis, or scarring, of the liver. This scarring sometimes leads to cirrhosis or liver cancer. What is alcohol-associated liver disease (ALD)? ALD is caused by heavy alcohol use. It used to be called alcoholic fatty liver disease, or alcoholic steatohepatitis. Your liver breaks down most of the alcohol you drink, so it can be removed from your body. But the process of breaking it down can create harmful substances. These substances can damage liver cells, cause inflammation, and weaken your body's natural defenses. The more alcohol that you drink, the more you damage your liver. ALD is the earliest stage of alcohol-related liver disease. The next stages are alcoholic hepatitis and cirrhosis. Who is more likely to develop steatotic liver disease? The cause of MASLD is unknown, but it is more common in people who: - Have type 2 diabetes and prediabetes - Have obesity - Are middle aged or older (although children can also get it) - Have high cholesterol or triglycerides - Have high blood pressure - Take certain medicines, such as corticosteroids and some cancer medicines - Have certain metabolic disorders, including metabolic syndrome - Have rapid weight loss - Have certain infections, such as hepatitis C - Have been exposed to certain harmful substances MASLD is the most common chronic (long-term) liver disease due to increasing rates of obesity, type 2 diabetes, and high cholesterol. ALD only happens in people who are heavy drinkers, especially those who have been drinking for a long period of time. The risk is higher for people who drink heavily and are women, have obesity, or have certain gene changes (known as variants or mutations). What are the symptoms of steatotic liver disease? Both MASLD and ALD usually have few or no symptoms. If you do have symptoms, you may feel tired or have discomfort in the upper right side of your abdomen (belly). How is steatotic liver disease diagnosed? Because there are often no symptoms, it's not easy to find steatotic liver disease. Your health care provider may suspect you have it if you have abnormal results on liver tests. To make a diagnosis, your provider may use: - Your medical history. This may include asking about your alcohol use and any medicines you take. - A physical exam. This may include checking your height and weight. Your provider may also check your body for signs of liver disease such as an enlarged liver or jaundice, a condition that causes your skin and whites of your eyes to turn yellow. - Blood tests. These may include liver function tests and blood count tests. - Imaging tests. These tests may be used to check for fat in the liver and for fibrosis. - A biopsy. In some cases, a biopsy may be done to confirm the diagnosis and check for liver damage. What are the treatments for steatotic liver disease? The first step in treating MASLD is usually weight loss. Losing weight can reduce fat in the liver, inflammation, and fibrosis. If your provider thinks that a certain medicine is the cause of your MASLD, they may tell you to stop or switch medicines. But don't stop taking any medicines unless your provider tells you to. More studies are needed to see whether certain medicines are safe and effective to treat MASLD. Currently, no medicines are approved for treatment. The most important part of treating ALD is to stop drinking alcohol. If you need help, you may benefit from counseling, a recovery program, or medicines that reduce cravings or make you feel sick if you drink alcohol. Both ALD and one type of MASLD can lead to cirrhosis. Health problems caused by cirrhosis may be treated with medicines, surgery, and other medical procedures. If cirrhosis leads to liver failure, you may need a liver transplant. What are some lifestyle changes that can help with steatotic liver disease? If you have any type of steatotic liver disease, there are some lifestyle changes that can help: - Eat a healthy diet, limiting salt and sugar, plus eating lots of fruits, vegetables, and whole grains. - Talk with your provider about vaccinations. If you have chronic liver disease you are more likely to get infections. Your provider may recommend vaccinations for hepatitis A and B, the flu and pneumococcal disease. - Get regular exercise, which can help you lose weight and reduce fat in the liver. Check with your provider before using dietary supplements, such as vitamins, or any complementary or alternative medicines or medical practices. Some supplements or herbal remedies can damage the liver.

US source; availability in Australia may differ.

Source: MedlinePlus Health Topics (medlineplus.gov), public domain (U.S. National Library of Medicine). Read the full source.

Sources and dates

ClinicalTrials.gov – trial records, statuses and site lists
MedlinePlus – the About text above, reproduced exactly
ClinicalTrials.gov processing date: 15 October 2026.
This page last checked by Voxsanity: 15 October 2026.

Voxsanity reformats data from public registries into this layout. It does not edit, interpret or add to what the registry published.

Not medical advice.

Individual trial records are refreshed on a rolling basis rather than all at once, so a record may be up to several weeks old. Each trial page and trial card shows the date its own record was last synced. Where a record has lagged, its status, sites and enrolment can differ from the current registry state in either direction, so check the registry link on the trial page before acting on them.

Questions to ask your doctor

General questions, the same on every condition page. Print this page to take them with you.

Is a clinical trial something I should consider at this point?
What would taking part involve week to week?
What are the risks, and what happens if I change my mind?
Would being in a trial change the care I get now?
Who would I see, and how far would I need to travel?
Are there costs, and is travel or time off work covered?
Can you refer me, or do I contact the trial site myself?

Is a medicine on the PBS?

Search the PBS on the Pharmaceutical Benefits Scheme's own website. Voxsanity does not publish PBS listings.

Where to get support

Fatty liver disease falls under the Liver Foundation's national work on liver health.

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Non-Alcoholic Fatty Liver Disease

At a glance

Where the trials are

Trials for Non-Alcoholic Fatty Liver Disease

Phase 1 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 1 study for people with Non-Alcoholic Fatty Liver Disease

Phase 1 study for people with Non-Alcoholic Fatty Liver Disease

Phase 1 study for people with Non-Alcoholic Fatty Liver Disease

Trials not shown here

Trials overseas

About Non-Alcoholic Fatty Liver Disease

Sources and dates

Tell us which conditions matter to you

Non-Alcoholic Fatty Liver Disease

At a glance

Where the trials are

Trials for Non-Alcoholic Fatty Liver Disease

Phase 1 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 3 study for people with Non-Alcoholic Fatty Liver Disease

Phase 1 study for people with Non-Alcoholic Fatty Liver Disease

Phase 1 study for people with Non-Alcoholic Fatty Liver Disease

Phase 1 study for people with Non-Alcoholic Fatty Liver Disease

Trials not shown here

Trials overseas

About Non-Alcoholic Fatty Liver Disease

Sources and dates

Tell us which conditions matter to you

Related conditions