Phase 3 Non-Alcoholic Fatty Liver Disease Trial, Recruiting NCT06632457 Sponsor: Boehringer Ingelheim Condition: Non-Alcoholic Fatty Liver Disease
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Phase 3 Non-Alcoholic Fatty Liver Disease Trial, Recruiting

NCT06632457
Recruiting Phase 3 🇦🇺 Australian site

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You are 18 years of age or older (or the legal age of consent in your country, if higher)
  • Your body mass index (BMI) is 27 or above (or 25 or above if you are of Asian background) — BMI is a measure based on your height and weight
  • You have been diagnosed with a specific liver condition called MASH cirrhosis, where scarring of the liver is present but the liver is still functioning (confirm with trial site)
  • Certain scan or imaging results show a specific level of fat in your liver, or you have had a recent liver biopsy showing liver fat or inflammation (confirm with trial site for exact requirements)
  • There are additional inclusion requirements not listed here (confirm with trial site)

Who may not be able to join:

  • You have drunk heavily in the last 5 years — above roughly 14 drinks per week for women or 21 drinks per week for men, for more than 3 months in a row
  • Your liver disease has reached a certain level of severity based on a medical scoring system called the MELD score (confirm with trial site)
  • You have had, or currently have, serious liver complications such as internal bleeding related to liver pressure, fluid build-up in the abdomen, or a type of brain confusion caused by liver disease
  • Certain blood test results at the screening stage fall outside acceptable ranges, including low protein levels, abnormal clotting, high bilirubin, high liver enzymes, or low platelet counts (confirm with trial site for exact values)
  • You have another long-term liver disease, such as autoimmune hepatitis, primary biliary cholangitis, Wilson's disease, or a genetic iron storage disorder, among others
  • You have hepatitis B or a history of long-term hepatitis B infection
  • You currently have hepatitis C infection
  • Your liver enzyme levels (AST and/or ALT) are more than 5 times the normal upper limit
  • Your liver disease is caused by alcohol or by a medication or drug
  • You have previously had a liver transplant or are currently on a waiting list for one
  • You have previously had a procedure to manage high blood pressure in the liver (such as a TIPS procedure)
  • There are additional exclusion requirements not listed here (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 22 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Phone: 1-800-243-0127

Australian sites

Concord Repatriation General Hospital, Concord, New South Wales
Nepean Hospital, Kingswood, New South Wales
1800271035
Liverpool Hospital, Liverpool, New South Wales
1800271035
Westmead Hospital, Westmead, New South Wales
1800271035
Monash Health, Clayton, Victoria
1800271035
Austin Health, Heidelberg, Victoria
1800271035
Royal Melbourne Hospital, Parkville, Victoria
1800271035
Royal Perth Hospital, Perth, Western Australia
1800271035

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Registry
ClinicalTrials.gov
Start date
7 November 2024
Est. completion
5 June 2029

Where this trial is recruiting

🇦🇷 Argentina 🇦🇺 Australia 🇦🇹 Austria 🇧🇪 Belgium 🇧🇷 Brazil 🇧🇬 Bulgaria 🇨🇦 Canada 🇨🇱 Chile 🇨🇳 China 🇨🇿 Czechia 🇫🇷 France 🇬🇪 Georgia 🇩🇪 Germany 🇭🇺 Hungary 🇮🇳 India 🇮🇹 Italy 🇯🇵 Japan 🇯🇴 Jordan 🇰🇿 Kazakhstan 🇲🇾 Malaysia 🇲🇽 Mexico 🇳🇱 Netherlands 🇳🇿 New Zealand 🇵🇱 Poland Puerto Rico 🇷🇴 Romania 🇸🇦 Saudi Arabia 🇸🇬 Singapore 🇿🇦 South Africa 🇰🇷 South Korea 🇪🇸 Spain 🇨🇭 Switzerland 🇹🇼 Taiwan Turkey (Türkiye) 🇬🇧 United Kingdom 🇺🇸 United States

8 site(s) in Australia. Confirm current status and contact details directly with the trial site.

Primary endpoints

Time to first occurrence of any component of the composite clinical endpoint (at EoS) consisting of: all-cause mortality, liver transplant, hepatic decompensation events, worsening of MELD score to ≥15 and progression to CSPH

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 22 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov