Phase 3 Non-Alcoholic Fatty Liver Disease Trial, Recruiting NCT06632444 Sponsor: Boehringer Ingelheim Condition: Non-Alcoholic Fatty Liver Disease
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Phase 3 Non-Alcoholic Fatty Liver Disease Trial, Recruiting

NCT06632444
Recruiting Phase 3 🇦🇺 Australian site

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You are 18 years old or older (or the legal adult age in your country) at the time you give consent
  • You have been diagnosed with MASH (a liver condition also known as non-alcoholic fatty liver disease) with a disease activity score of 4 or higher
  • Your body weight has been stable, meaning it has changed by less than 5% in the 3 months before screening, or between your previous liver biopsy and the start of the trial
  • You are willing to keep your diet and physical activity levels consistent throughout the whole trial
  • Note: Additional inclusion criteria may apply — confirm with the trial site

Who may not be able to join:

  • Your liver blood test results at screening show certain abnormalities, such as significantly elevated liver enzymes, a low platelet count, or other signs that your liver is not functioning normally (confirm with trial site for specific values)
  • You have any history or current signs of a liver disease other than MASH
  • You have been diagnosed with liver cirrhosis (the most advanced stage of liver scarring, known as stage F4)
  • You have been diagnosed with, or have a history of, liver cancer (hepatocellular carcinoma)
  • You have had, or are planning to have, a liver transplant
  • You are unable or unwilling to have a liver biopsy as part of the trial, if a suitable previous biopsy is not available
  • You have a history of high blood pressure in the liver (portal hypertension) or signs of serious liver failure
  • Your liver disease severity score (called a MELD score) is 12 or higher
  • Note: Additional exclusion criteria may apply — confirm with the trial site

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 12 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Phone: 1-800-243-0127

Australian sites

Concord Repatriation General Hospital, Concord, New South Wales
1800271035
Nepean Hospital, Kingswood, New South Wales
1800271035
Liverpool Hospital, Liverpool, New South Wales
1800271035
Westmead Hospital, Westmead, New South Wales
1800271035
Sunshine Coast University Hospital, Birtinya, Queensland
1800271035
Monash Health, Clayton, Victoria
1800271035
Austin Health, Heidelberg, Victoria
1800271035
Royal Melbourne Hospital, Parkville, Victoria
1800271035
Royal Perth Hospital, Perth, Western Australia
1800271035

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Registry
ClinicalTrials.gov
Start date
17 September 2024
Est. completion
27 December 2031

Where this trial is recruiting

🇦🇷 Argentina 🇦🇺 Australia 🇦🇹 Austria 🇧🇪 Belgium 🇧🇷 Brazil 🇧🇬 Bulgaria 🇨🇦 Canada 🇨🇱 Chile 🇨🇳 China 🇨🇿 Czechia 🇫🇷 France 🇬🇪 Georgia 🇩🇪 Germany 🇭🇺 Hungary 🇮🇳 India 🇮🇹 Italy 🇯🇵 Japan 🇯🇴 Jordan 🇰🇿 Kazakhstan 🇲🇾 Malaysia 🇲🇽 Mexico 🇳🇱 Netherlands 🇳🇿 New Zealand 🇵🇱 Poland Puerto Rico 🇷🇴 Romania 🇸🇦 Saudi Arabia 🇸🇬 Singapore 🇿🇦 South Africa 🇰🇷 South Korea 🇪🇸 Spain 🇨🇭 Switzerland 🇹🇼 Taiwan Turkey (Türkiye) 🇬🇧 United Kingdom 🇺🇸 United States

9 site(s) in Australia. Confirm current status and contact details directly with the trial site.

Primary endpoints

Part 1: Resolution of MASH without worsening of liver fibrosis on MASH Clinical Research Network (CRN) fibrosis score; Part 1: At least a 1-point improvement in fibrosis stage with no worsening of MASH; Part 2: Time to first occurrence of any of components of the composite endpoint consisting of progression to cirrhosis, all-cause mortality, liver transplant, hepatic decompensation event(s), worsening of MELD score to ≥15, progression to CSPH

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 12 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov