Phase 2 Melanoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older.
• People who have been diagnosed with chronic lymphocytic leukemia (CLL) or small lymphocytic leukemia (SLL), confirmed using standard 2018 diagnostic guidelines.
• People who have had at least one non-melanoma skin cancer diagnosed within the last 5 years.
• People whose liver is functioning well enough to meet specific blood test thresholds set by the trial (confirm with trial site for exact values).
• Women who are post-menopausal, have had surgical sterilization, or have a negative pregnancy test — with specific requirements depending on age and medical history (confirm with trial site for details).
• Women who are able to become pregnant, and men whose sexual partner is able to become pregnant, where both agree to use a highly effective form of contraception during the trial.

Who may not be able to join:

• People who have received certain chemotherapy drugs (such as fludarabine, cyclophosphamide, bendamustine, or chlorambucil) within the last 6 months.
• People who have had an allogeneic stem cell transplant (a transplant using donor cells) within the last 6 months.
• People who have taken nicotinamide or niacin supplements within the last 4 weeks.
• People who have taken acitretin or other oral retinoids (a type of vitamin A-based medicine) within the last 6 months.
• People who have had certain skin treatments for actinic keratoses (pre-cancerous skin spots), such as specific creams, light-based therapy, laser, or chemical peels, within the last 4 weeks.
• People who have large areas of skin cancer that are joined together, making it difficult to count individual new skin cancers.
• People who need to continue taking carbamazepine (a medicine used for seizures or nerve pain), due to a possible interaction with the trial treatment.
• People who have a serious condition affecting their gut's ability to absorb nutrients, which may prevent the trial treatment from being absorbed properly (the trial doctor will assess this).
• People whose life expectancy is estimated to be less than 2 years.
• People with uncontrolled diabetes.
• People with a current or past history of peptic ulcer disease (stomach or intestinal ulcers).
• People with HIV who have had a detectable viral load within 6 months before the expected start of treatment. (Note: people with HIV who are on effective treatment and have had an undetectable viral load within that same period may still be considered eligible — confirm with trial site.)
• People with an active infection that is not under control.
• People with medical, psychiatric, cognitive, or other conditions that may affect their ability to understand the trial information, give consent, or follow the study requirements.
• People who have had a severe allergic reaction (Grade 3 or higher) to the trial treatment or any of its ingredients.
• People currently taking certain medications that are not permitted in the trial, without completing an appropriate washout period beforehand (confirm with trial site for the specific list of prohibited medications).
• People who have had a solid organ transplant (such as a kidney or liver transplant) and are currently taking immunosuppressive medications (medicines to prevent organ rejection).

Important: Always verify eligibility with the trial site directly before applying.