Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are at least 18 years old
• People who are able to understand the study's purpose and risks, and who have signed a written consent form approved by the ethics committee
• People who have been diagnosed with glioblastoma (a type of brain tumour), confirmed through laboratory testing of tissue
• People whose glioblastoma has come back or grown after standard treatment with radiation therapy and temozolomide chemotherapy
• People whose general physical condition meets a certain level of functioning, meaning they are able to carry out at least some daily activities (confirm with trial site for exact level required)
• People who are expected to live for at least 3 months
• People whose liver function blood tests fall within acceptable ranges (confirm with trial site for exact values)
• People whose kidney function blood tests fall within acceptable ranges (confirm with trial site for exact values)
• People whose blood counts — including white blood cells, platelets, and haemoglobin — fall within acceptable ranges without needing blood-support treatments
• Women who could become pregnant must have a negative pregnancy blood test before joining; both men and women must agree to use effective contraception during the trial and for 6 months after the last dose

Who may not be able to join:

• People taking warfarin or similar blood-thinning medications who are unable to switch to a different type of blood thinner before starting the trial
• People who have signs of active bleeding in the brain or tumour on a brain scan (people with minor, settled bleeding changes may still be considered)
• People who are unable to have an MRI scan, for example due to having a pacemaker
• People who have taken certain seizure medications (such as carbamazepine, phenytoin, phenobarbital, or primidone) within 14 days before starting the trial
• People who are still experiencing significant side effects from previous surgery, chemotherapy, or other treatments (minor side effects such as hair loss, anaemia, or low lymphocyte counts may be acceptable — confirm with trial site)
• People who have a wound that has not properly closed or healed
• People who are pregnant or breastfeeding
• People with a history of heart conditions, including irregular heartbeat, heart attack, unstable chest pain, or heart failure
• People whose heart's electrical activity shows a prolonged interval on a heart tracing (ECG) above a certain threshold
• People with high blood pressure that remains above certain levels despite treatment
• People with wounds, ulcers, or bone fractures that have not healed
• People with an underactive thyroid that has not been treated
• People with an unhealed abscess in or around the rectum
• People with an active infection that is not under control
• People who have had a stroke or a mini-stroke (transient ischaemic attack) within the past 6 months
• People who have previously received certain types of radiation therapy (such as brachytherapy or internal radioisotope therapy), though stereotactic radiosurgery is allowed
• People who have received certain other cancer treatments within specific time periods before the trial starts (confirm with trial site for exact timeframes and medications)
• People who have previously been treated with carmustine wafers (a type of chemotherapy implanted in the brain)
• People who currently have psychosis, an uncontrolled mood disorder, or thoughts of suicide, or who have a history of bipolar disorder
• People currently taking certain antidepressants or related medications (including SSRIs, SNRIs, MAO inhibitors, tramadol, or trazodone) who are not willing to gradually reduce and stop these medications

Important: Always verify eligibility with the trial site directly before applying.