Phase 3 PTSD Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years old or older
• You are a U.S. military veteran
• You have been diagnosed with PTSD, either by a doctor or confirmed by the study team
• Your score on a PTSD symptom checklist (called the PCL-5) is at least 40
• Your PCL-5 scores show a high enough level of certain PTSD symptoms, including intrusive thoughts or emotional/physical reactions (confirm with trial site for exact scoring details)
• Your responses on the PCL-5 questionnaire meet specific minimum scores across several symptom categories (confirm with trial site for exact details)
• You experience nightmares at a level of at least 3 on a specific clinical rating scale
• You speak and understand English
• You are willing and able to attend clinic visits as scheduled

Who may not be able to join:

• You are currently pregnant or breastfeeding
• You are considered at moderate or high risk for suicide based on a recent standardized safety screening
• You have an unstable or active serious mental health condition, or cognitive difficulties that the study doctor believes would get in the way of participating (for example, active schizophrenia, uncontrolled bipolar disorder, a history of significant memory or thinking problems, or a moderate to severe brain injury)
• You are currently receiving a type of therapy called exposure therapy
• You recently started (within the last month) another mental health or behavioral therapy program (the study doctor will decide on a case-by-case basis)
• Your blood pressure is too high — above 160/100 — or you are experiencing a blood pressure emergency
• Your blood pressure is too low — below 100/60 — or you have symptoms of low blood pressure such as dizziness, lightheadedness, or heart palpitations
• You have a known allergy or sensitivity to a medication called clonidine
• You have a history of certain heart conditions, including specific types of heart rhythm problems (confirm with trial site for full details)
• You have a history of a tumor called pheochromocytoma
• You have a history of a circulation condition called Raynaud's phenomenon
• You have stage 5 kidney disease
• You had a heart attack within the last 6 months
• You have a history of stroke or blood vessel disease in the brain, or had a stroke within the last 6 months
• You have used any of the following substances without a prescription, or not as prescribed, in the past 30 days: heroin, opioid painkillers, barbiturates, sedatives or tranquilizers, cocaine, amphetamines, cannabis, hallucinogens, or inhalants
• You currently have a diagnosed substance use disorder involving opioids, cocaine, alcohol, or cannabis
• You have been diagnosed with sleep apnea and have said you are not following your prescribed treatment for it
• You have been prescribed certain medications within the last 6 months, including: clonidine or similar blood pressure medications (alpha-2 agonists), certain other blood pressure medications (alpha-1 blockers such as prazosin or tamsulosin), opioid medications, antipsychotic medications, benzodiazepines, or a medication called cyproheptadine (confirm with trial site for the full list)
• The study doctor or team determines that you are not able to fully participate due to cognitive difficulties
• You have a legal guardian

Important: Always verify eligibility with the trial site directly before applying.