Phase 1 Thyroid Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 85 years old.
• People who have been diagnosed with a specific type of thyroid cancer (called papillary or follicular thyroid carcinoma, together known as differentiated thyroid carcinoma), confirmed through a tissue sample, that has not fully responded to initial surgery with or without radioiodine (iodine-131) treatment, as shown on imaging scans (CT, MRI, or ultrasound).
• People whose thyroid cancer cannot be fully removed by surgery because it has grown into the soft tissues of the neck, or because there are distant cancer deposits that cannot be surgically removed.
• People whose cancer still absorbs iodine, but at a level too low to be effectively treated by radioiodine therapy alone, as shown on a prior diagnostic or treatment scan.
• People with adequate kidney function (confirmed by specific blood or scan-based tests) and adequate blood cell counts (platelets and a type of white blood cell called neutrophils must be above certain levels).
• People with a life expectancy of at least 8 weeks.
• People who are well enough to carry out more than half of normal daily activities, as measured by a standard medical scoring tool called the Karnofsky Performance Scale (confirm with trial site).
• People who have sufficiently recovered from any previous chemotherapy side effects, with most side effects having settled to a mild or better level (as assessed by the treating doctor and study team).
• People who have a known history of heart disease may still be considered eligible, as the treatment used in this trial is not expected to affect heart function.

Who may not be able to join:

• People who are pregnant or breastfeeding.
• People who are sexually active, have not yet gone through menopause, and do not agree to use an accepted and effective form of contraception during the trial.
• People who have any medical reason that would make radioiodine therapy or external beam radiation therapy (targeted radiation treatment) unsafe for them.
• People whose cancer is considered lower-risk according to certain medical guidelines, and who do not meet the criteria for either radioiodine therapy or external beam radiation treatment under those guidelines.
• People who have advanced cancer that has spread to the brain or spinal cord, or who have critical tumours affecting the hip or spine, where receiving radioiodine treatment before radiation therapy could be harmful — particularly due to the hormone stimulation required as part of the treatment process.
• People who have received iodine-containing contrast dye (used in certain imaging scans) within the past 6 weeks, as this may reduce the effectiveness of radioiodine treatment.

Important: Always verify eligibility with the trial site directly before applying.