Phase 1 Obesity Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People aged between 18 and 79 years old, of any gender
- People with a BMI (body mass index) over 30, which is generally considered obese
- People with high blood pressure, specifically a reading above 130/80
- People with elevated insulin resistance, measured by a specific blood test called HOMA-IR with a score above 2.5 (confirm with trial site)
- People with a waist measurement greater than 102 cm for men, or greater than 88 cm for women
- People with a fasting blood sugar level below 126 mg/dL (measured after not eating)
- People with fasting triglyceride levels (a type of fat in the blood) below 250 mg/dL
- People with an HbA1c level (a measure of average blood sugar over time) below 6.5%
- People who are willing and able to visit the research lab at Fairway CTSU
- People who are willing to have a blood sample taken
- People who are able to sign a written consent form agreeing to participate
Who may not be able to join:
- People who currently take clonidine or beta-blockers (certain types of blood pressure or heart medications)
- People who currently smoke, or who have smoked within the past 3 months
- People with high triglyceride levels (a type of fat in the blood) above 250 mg/dL
- People who are currently taking any medication for high blood pressure
- People who have a history of heart disease, including heart attack, stroke, heart failure, stents, bypass surgery, valve problems, or cardiomyopathy (a disease of the heart muscle)
- People who have a history of neurological disorders (conditions affecting the brain or nervous system)
- People who have had an organ or tissue transplant
- People who are currently taking part in another research study, unless it is a registry study only
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Seth W. W Holwerda, PhD, University of Kansas Medical Center
Phone: 9729223230
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Blood Work: Efficacy of 4-week supply of Clonidine Compared VS 4-week supply of control condition using hydrochlorothiazide (HCTZ) and a separate placebo treatment; Endothelial Cell Sample: Efficacy of 4-week supply of Clonidine Compared VS 4-week supply of control condition using hydrochlorothiazide (HCTZ) and a separate placebo treatment; Adipose Tissue Sample: Efficacy of 4-week supply of Clonidine Compared VS 4-week supply of control condition using hydrochlorothiazide (HCTZ) and a separate placebo treatment; Blood Work: Efficacy of 4-week supply of Clonidine Compared VS 4-week supply of c...
Can't join this trial?
Data last synced from ClinicalTrials.gov: 14 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.