Phase 1 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been newly diagnosed with a specific type of brain tumor called DIPG or DMG, confirmed either by biopsy or by brain imaging that meets specific criteria (confirm with trial site for details on imaging requirements)
• The tumor must have a confirmed histone mutation, shown on a pathology report (confirm with trial site)
• Children and young people aged 12 months to 18 years (note: for certain parts of the trial, the first three patients enrolled must be aged 12 years or older)
• People whose body surface area (a measurement based on height and weight) is at least 0.35 m² at the time of joining the trial
• People who meet a minimum physical functioning score, measured using standard scales used by doctors to assess daily activity and mobility — wheelchair users who cannot walk due to paralysis may still meet this criterion (confirm with trial site)
• People who are able to start radiation therapy within 42 days of their diagnostic scan, and begin the trial treatment between 6 and 10 weeks after finishing radiation
• People whose steroid medication (if prescribed) has been reduced to a low dose for at least 7 days before joining
• People whose tumor can be measured on scans

Who may not be able to join:

• People who received a chemotherapy drug called temozolomide during their radiation treatment
• People whose cancer has spread beyond the original tumor site (disseminated disease)
• People who have received any cancer treatment other than radiation therapy
• People with autoimmune conditions or immune system disorders
• People with an active breathing or respiratory condition or infection
• People with an active viral infection

Important: Always verify eligibility with the trial site directly before applying.