Early Phase 1 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 75 years old
• People who have been confirmed by tissue testing to have a primary, returned, or spread brain glioma (a type of brain tumour)
• People whose life expectancy is estimated to be more than 3 months
• People who have a reasonable level of general physical functioning, as assessed by their doctor using standard scoring tools (confirm with trial site)
• People whose standard treatment options have not worked, or for whom no standard treatments are available
• People who have a tumour area that a surgeon can sample or remove, or a body fluid from which immune cells can be collected
• People who have at least one measurable tumour that can be tracked during the trial
• People whose recent blood test results (taken within 7 days before joining) show that white blood cells, infection-fighting cells, immune cells, platelets, and haemoglobin are all at or above minimum levels, and that kidney, liver, and blood-clotting results are within acceptable ranges (confirm specific values with trial site)
• People who have no medical reason preventing them from having a biopsy or surgery
• People of childbearing potential who are willing to use highly effective contraception from the time of agreeing to join, and for one year after a specific part of the treatment is completed
• People who have stopped any cancer-targeting treatments — including radiotherapy, chemotherapy, or biological therapies — at least 28 days before immune cells are collected
• People who are able to understand and sign the consent form
• People who are able to attend follow-up visits and meet the other requirements of the trial

Who may not be able to join:

• People who need steroid medications (such as prednisone) at a daily dose above 15mg, or who need immune-suppressing treatment for an autoimmune condition
• People with significantly reduced lung function, based on specific breathing test measurements (confirm with trial site)
• People with serious heart conditions, such as severe heart failure, uncontrolled coronary artery disease, very low blood pressure, poor heart pumping function, or significant heart rhythm or electrical conduction problems
• People who have HIV infection or a positive HIV antibody test, active hepatitis B or C infection, or a syphilis infection
• People with serious physical or mental health conditions
• People who have an active infection throughout the body that requires treatment, or who have had a positive blood culture or imaging showing signs of infection
• People who have received or are currently receiving other medicines, biological therapy, chemotherapy, or radiotherapy within the past month
• People with a known allergy to substances similar to those used in cell-based therapies
• People who have previously received immunotherapy and experienced a serious immune-related side effect rated at level 3 or above
• People who still have significant side effects (above a mild level) from previous cancer treatments that have not resolved
• People who are pregnant or breastfeeding
• People who have previously had an organ transplant, a bone marrow or stem cell transplant from a donor, or kidney replacement therapy (such as dialysis)
• People who, in the opinion of the trial doctor, have other serious health conditions or circumstances that make participation unsuitable

Important: Always verify eligibility with the trial site directly before applying.