Phase 3 Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Chinese females between 9 and 26 years old who are generally healthy, and who can provide valid identification.
• People who are willing to take part in the study voluntarily; if the person is a minor, both the minor and their legal guardian must agree and sign a consent form.
• People of childbearing age who have a negative pregnancy test on the day of enrolment, are not currently breastfeeding, have no plans to become pregnant within 7 months, and are using an effective form of contraception (confirm with trial site).
• People without a fever on the day of enrolment — specifically, those aged over 14 must have an underarm temperature below 37.3°C, and those aged 14 or under must have an underarm temperature below 37.5°C.
• People who are able to understand what the study involves and are willing to attend regular follow-up appointments as required.

Who may not be able to join:

• People who have already received a commercially available HPV vaccine, plan to receive one during the study, or have previously taken part in an HPV vaccine clinical trial.
• People who are currently enrolled in, or planning to join, another clinical trial for a drug or vaccine.
• People who have previously tested positive for HPV, have a history of cervical cancer or abnormal cervical screening or biopsy results (including CIN, LSIL, or cervical cancer), or have had pelvic radiation therapy.
• People with a history of conditions linked to HPV infection, such as genital warts or related cancers, or a history of sexually transmitted infections such as syphilis, gonorrhoea, or genital herpes, among others.
• People with a known allergy to any ingredient in the vaccine, or a history of severe allergic reactions requiring treatment, such as anaphylactic shock, throat swelling, hives, or similar serious reactions.
• People with a primary or acquired immune deficiency condition, such as HIV, lupus (SLE), or juvenile rheumatoid arthritis (JRA).
• People with a history of epilepsy or seizures, except for febrile (fever-related) seizures that occurred before age 5.
• People with existing infectious diseases such as tuberculosis, viral hepatitis, or HIV, or existing liver, kidney, heart, or cancer-related conditions.
• People with high blood pressure that is not being treated or is not under control — for those aged 9 to 17, this means a reading at or above 120/80 mmHg; for those aged 18 and over, a reading at or above 140/90 mmHg.
• People with blood clotting disorders or low platelet counts.
• People who do not have a spleen, or whose spleen does not function properly, for any reason.
• People who have received immune-suppressing treatments (such as high-dose steroid medications for more than two weeks) within the past month, or who plan to receive such treatments during the first seven months of the study.
• People who have received immune globulin or blood-derived products within the past 3 months, or who plan to receive such products during the first seven months of the study.
• People who, in the 3 days before vaccination, have had an acute illness, an acute flare-up of a chronic condition, or have taken fever-reducing, pain-relieving, or anti-allergy medications such as paracetamol, ibuprofen, aspirin, loratadine, or cetirizine.
• People who have received an inactivated, RNA, or recombinant vaccine within the past 14 days, or a live vaccine within the past 28 days.
• People with a current or past history of mental illness, or a family history of mental illness.
• People who, in the investigator's judgement, have any condition that could interfere with the study or mean that taking part may not be in their best interest.

Important: Always verify eligibility with the trial site directly before applying.