Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who were 18 years of age or older when their brain metastases were diagnosed
• People whose general physical functioning is relatively good, meaning they are able to carry out most daily activities (confirmed using a standard medical scale called the ECOG score, which must be below 2)
• People who have a solid tumour cancer confirmed by a tissue or cell sample, with spots in the brain that imaging or testing shows are likely or confirmed to be cancer that has spread there
• People who have previously received systemic cancer treatments (such as chemotherapy or targeted therapy) are still eligible
• People whose cancer outside the brain is not expected to cause death within the next six months
• People who have at least one brain metastasis that can be measured on imaging
• People who have previously had treatment for brain metastases — including a type of focused radiation called stereotactic radiosurgery or surgery to remove a tumour — as long as that treatment was completed at least 7 days before joining (for radiosurgery) or at least 14 days before joining (for surgical removal)
• People who have had an open surgical biopsy must be at least one week past that procedure before joining (this wait does not apply to stereotactic biopsies)
• People whose kidneys are filtering at a rate of at least 30 mL/min (a measure of kidney function)
• People who are able to begin the study radiation treatment within two weeks of registering for the trial
• People who are able to complete a set of memory and thinking tests, including those whose first language is English
• People who have had another cancer in the past or have a second cancer that is under control and not affecting their general functioning or life expectancy
• People who are willing and able to give informed consent and follow the treatment and follow-up schedule

Who may not be able to join:

• People whose cancer started in the blood or lymphatic system (such as leukaemia or lymphoma), or whose cancer started in the brain or spinal cord itself
• People whose cancer is being treated with the aim of a complete cure
• People whose cancer has spread to the lining surrounding the brain and spinal cord (a condition called leptomeningeal metastases)
• People who cannot have an MRI scan with contrast dye (for example, due to an allergy or other medical reason)
• People who cannot take a medication called memantine, including those already taking a certain type of drug that works on the same part of the brain (called NMDA antagonists)
• People with stage 4 or 5 chronic kidney disease, or end-stage kidney failure
• People who have a brain tumour larger than 5 cm across that has not been surgically removed
• People who have previously had whole-brain radiation therapy
• People who have a diagnosis of dementia that is believed to be unrelated to their brain metastases
• Women who could become pregnant, who are known to be pregnant, or who are unwilling to use an acceptable form of contraception from the time of consent until the end of the radiation treatment course
• People who have a serious medical or psychiatric condition that, in their treating doctor's view, would prevent them from giving informed consent or completing the trial treatment and follow-up visits
• People whose first language is not English, due to the potential impact of cognitive decline on performance in the verbal thinking tests used in this trial (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.